Chemical investigation of the Okinawan soft coral Clavularia koellikeri resulted in the isolation of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid, 3. Their structures were determined on the basis of the results of spectroscopic analysis. Compounds 1 and 3 were examined for in vitro growth-inhibition effects toward tumor cells.
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http://dx.doi.org/10.1021/np0200156 | DOI Listing |
Biofouling
January 2025
The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan.
Nat Prod Bioprospect
March 2022
Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa, 903-0213, Japan.
One new furanocembranoid diterpene, 11-hydroxy-Δ-pukalide (1), along with six known secondary metabolites, 11-acetoxy-Δ-pukalide (2), 13α-acetoxypukalide (3), pukalide (4), 3α-methoxyfuranocembranoid (5), Δ-africanene (6), and methyl (5'E)-5-(2',6'-dimethylocta-5',7'-dienyl)furan-3-carboxylate (7) were isolated from the Okinawan soft coral Sinularia sp. Their chemical structures were elucidated based on spectroscopic analysis (FTIR, NMR, and HRESIMS), and the relative stereochemistry of 1 was determined by NOESY experiments and acetylation, which yielded derivative 2. In addition, compounds 1 and 7 exhibited toxicity in the brine shrimp lethality test.
View Article and Find Full Text PDFMolecules
July 2021
Department of European Cultures (DICEM), University of Basilicata, 75100 Matera, Italy.
Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the , , genera. Corals, , Okinawan/, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances.
View Article and Find Full Text PDFFitoterapia
July 2019
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan. Electronic address:
Three new cembranolides (1-3) were isolated from an Okinawan soft coral, Lobophytum sp., together with the known cembranolide diterpenoids (4-9). Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS), molecular modeling, and comparison with data reported elsewhere.
View Article and Find Full Text PDFMar Drugs
September 2018
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan.
Our current study demonstrated that the marine peroxy sesquiterpenoids isolated from the Okinawan soft coral sp. have an antitumor activity in human colon cancer cell (HCT) 116 colon cancer cells with their induction of apoptosis due to H₂O₂ production derived from the compounds. This study clarified that peroxy sesquiterpenoids ( and ) inhibited anti-apoptosis proteins, such as B-cell lymphoma-extra large (Bcl-xL) and phosphoAkt (pAkt).
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