New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri.

J Nat Prod

Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Japan.

Published: October 2002

AI Article Synopsis

  • A chemical study of the Okinawan soft coral Clavularia koellikeri led to the discovery of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid (3).
  • The structures of these compounds were identified using spectroscopic analysis techniques.
  • Compounds 1 and 3 were tested for their ability to inhibit the growth of tumor cells in laboratory experiments.

Article Abstract

Chemical investigation of the Okinawan soft coral Clavularia koellikeri resulted in the isolation of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid, 3. Their structures were determined on the basis of the results of spectroscopic analysis. Compounds 1 and 3 were examined for in vitro growth-inhibition effects toward tumor cells.

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http://dx.doi.org/10.1021/np0200156DOI Listing

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