For the purpose of detecting the effects of human activities on climate change, it is important to document natural change in past climate. In this context, it has proved particularly difficult to study the variability in the occurrence of extreme climate events, such as storms with exceptional rainfall. Previous investigations have established storm chronologies using sediment cores from single lakes, but such studies can be susceptible to local environmental bias. Here we date terrigenous inwash layers in cores from 13 lakes, which show that the frequency of storm-related floods in the northeastern United States has varied in regular cycles during the past 13,000 years (13 kyr), with a characteristic period of about 3 kyr. Our data show four peaks in storminess during the past 14 kyr, approximately 2.6, 5.8, 9.1 and 11.9 kyr ago. This pattern is consistent with long-term changes in the average sign of the Arctic Oscillation, suggesting that modulation of this dominant atmospheric mode may account for a significant fraction of Holocene climate variability in North America and Europe.
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http://dx.doi.org/10.1038/nature01132 | DOI Listing |
BMC Med Inform Decis Mak
January 2025
School of Medicine, University of Colorado, Aurora, CO, USA.
Background: In prehospital emergency care, providers face significant challenges in making informed decisions due to factors such as limited cognitive support, high-stress environments, and lack of experience with certain patient conditions. Effective Clinical Decision Support Systems (CDSS) have great potential to alleviate these challenges. However, such systems have not yet been widely adopted in real-world practice and have been found to cause workflow disruptions and usability issues.
View Article and Find Full Text PDFJ Neurosci
January 2025
Department of Ophthalmology, Harvard Medical School, Boston, MA, United States.
We employed high-resolution fMRI to distinguish the impacts of anisometropia and strabismus amblyopia on the evoked ocular dominance (OD) response. Sixteen amblyopic participants (8 females) plus 8 individuals with normal vision (1 female), participated in this study for whom, we measured the difference between the response to stimulation of the two eyes, across areas V1-V4.In controls, the evoked OD response formed the expected striped pattern within V1.
View Article and Find Full Text PDFJ Membr Biol
January 2025
Laboratório de Bioquímica Celular, Universidade Federal de São João del-Rei (UFSJ), Divinópolis, Brazil.
Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of current drugs. Cardiotonic steroids (CTS) interact with Na/K-ATPase (NKA) and induce antineoplastic effects, but their narrow therapeutic window is key limiting factor. The synthesis of digitoxigenin derivatives with glycosidic unit modifications is a promising approach to develop more selective and effective antitumor agents.
View Article and Find Full Text PDFJ Midwifery Womens Health
January 2025
College of Public Health, University of South Florida, Tampa, Florida.
Introduction: Birthing people around the world experience mistreatment during labor and birth, contributing to adverse maternal health outcomes. The adoption of respectful maternity care (RMC) has been recommended to address this mistreatment and improve care quality. Most RMC and mistreatment research has been conducted internationally.
View Article and Find Full Text PDFIntroduction: Physical Activity (PA) and its links to frailty, quality of life (QoL), and other comorbidities in older Ugandans living with HIV remain under-explored.
Methods: We analyzed data from three annual assessments of older people living with HIV (PLWH) and age- and sex-similar people not living with HIV (PnLWH). We fitted linear generalized estimating equations (GEE) regression models to estimate the correlates of PA, including demographics, frailty, QoL, HIV, and other comorbidities.
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