AI Article Synopsis
- Exposure to hypobaric hypoxia in rats led to increased lipid peroxidation, indicated by higher levels of TBARS in the brain.
- The study compared the protective effects of alpha-tocopherol, L-carnitine, and phosphocreatine on these changes, finding that all three helped reduce TBARS levels.
- However, only L-carnitine and phosphocreatine improved the lactate/pyruvate ratio, suggesting their protective effects are linked to metabolic regulation during hypoxia, unlike alpha-tocopherol, which acts as a scavenger.
Article Abstract
The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretreated with alpha-tocopherol, L-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/ pyruvate ratio was improved only in rats pretreated with L-carnitine or phosphocreatine. We conclude from our data that, contrary to alpha-tocopherol, protective effects of L-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity.
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| http://dx.doi.org/10.1023/a:1020339530924 | DOI Listing |
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