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Research on grading detection methods for diabetic retinopathy based on deep learning.
Pak J Med Sci
January 2025
Juan Chen, Department of Ophthalmology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Objective: To design a deep learning-based model for early screening of diabetic retinopathy, predict the condition, and provide interpretable justifications.
Methods: The experiment's model structure is designed based on the Vision Transformer architecture which was initiated in March 2023 and the first version was produced in July 2023 at Affiliated Hospital of Hangzhou Normal University. We use the publicly available EyePACS dataset as input to train the model.
An estrogen receptor β-targeted near-infrared probe for theranostic imaging of prostate cancer.
RSC Med Chem
December 2024
Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University Wuhan 430071 China
Estrogen receptor β (ERβ) is aberrantly expressed in castration-resistant prostate cancer (CRPC). Therefore, a diagnostic and therapeutic ERβ probe not only helps to reveal the complex role of ERβ in prostate cancer (PCa), but also promotes ERβ-targeted PCa therapy. Herein, we reported a novel ERβ-targeted near-infrared fluorescent probe D3 with both imaging and therapeutic functions, which had the advantages of high ERβ selectivity, good optical performance, and strong anti-interference ability.
View Article and Find Full Text PDFNeural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.
Biol Psychiatry Glob Open Sci
March 2025
Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Background: Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the behavioral and neural level have yielded equivocal findings that may be driven by small sample sizes and differences in study design. Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied.
View Article and Find Full Text PDFVaried Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series.
Cureus
December 2024
Neurology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND.
Introduction: This study discusses the various clinical profiles, investigatory findings, treatment responses, and prognosticating factors in seven cases of autoimmune encephalitis (AE).
Methods: The clinical records of seven AE patients admitted to the Neurology Department, SRM Medical College Hospital and Research Centre, Chennai, from July 2022 to December 2023 were retrospectively analyzed.
Results: The patients' ages ranged from 18 to 35, and all experienced seizures.
Text Message System for the Prediction of Colonoscopy Bowel Preparation Adequacy Before Colonoscopy: An Artificial Intelligence Image Classification Algorithm Based on Images of Stool Output.
Gastro Hep Adv
September 2024
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania.
Background And Aims: Inadequate bowel preparation which occurs in 25% of colonoscopies is a major barrier to the effectiveness of screening for colorectal cancer. We aim to develop an artificial intelligence (machine learning) algorithm to assess photos of stool output after bowel preparation to predict inadequate bowel preparation before colonoscopy.
Methods: Patients were asked to text a photo of their stool in the commode when they believed that they neared completion of their colonoscopy bowel preparation.
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