Objective: To investigate the association between porcine gastric epithelial cell proliferation and Helicobacter pylori (Hp) infection.
Method: Animal models of gastritis associated with Hp infection were established using "Chinese No.1 pigs". The expressions of proliferating cell nuclear antigen (PCNA) and DNA polyploid content in porcine gastric epithelial cells were quantitatively assayed by means of immunohistochemistry and Feulgen stain respectively.
Results: The values of PCNA labeling index (LI) in the porcine gastric epithelial cells of the experimental group were significantly higher than those of the control group (40.95+/-3.60 vs 29.4+/-12.82, P<0.01). The DNA diploid or approximate diploid content in the gastric mucosa of the pigs was significantly lower (70.78% vs 90.65%, P<0.01), but the proliferation polyploid and non-doubleploid of DNA significantly higher in the experimental group than in the control group (P<0.01).
Conclusion: Hp infection may play a role to enhance the proliferation of gastric epithelial cells in pigs.
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