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Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy-From Fundamentals to Applied Tactics.
Medicina (Kaunas)
December 2024
Clinic for Gastroenterology and Hepatology, University Clinical Centre of Serbia, 11 000 Belgrade, Serbia.
Cirrhotic cardiomyopathy (CCM) is a diagnostic entity defined as cardiac dysfunction (diastolic and/or systolic) in patients with liver cirrhosis, in the absence of overt cardiac disorder. Pathogenically, CCM stems from a combination of systemic and local hepatic factors that, through hemodynamic and neurohormonal changes, affect the balance of cardiac function and lead to its remodeling. Vascular changes in cirrhosis, mostly driven by portal hypertension, splanchnic vasodilatation, and increased cardiac output alongside maladaptively upregulated feedback systems, lead to fluid accumulation, venostasis, and cardiac dysfunction.
View Article and Find Full Text PDFApproach to Endocrine Hypertension: A Case-Based Discussion.
Curr Hypertens Rep
January 2025
Department of Endocrinology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India.
Purpose Of Review: Hypertension remains a major chronic disease morbidity across the world, even in the twenty-first century, affecting ≈40% of the global population, adversely impacting the healthcare budgets in managing the high incidence of cardiovascular disease (CVD) complications and mortality because of elevated blood pressure (BP). However, evaluation and management of endocrine hypertension are not optimal in clinical practice. With three unique clinical case scenarios, we update the evidence base for diagnostic evaluation and management of endocrine hypertension in this review to inform appropriate day-to-day clinical practice decisions.
View Article and Find Full Text PDFChildhood Hypertension: A Retrospective Analysis of Causes, Treatments, and Complications.
Children (Basel)
October 2024
Pediatric Nephrology Unit, Department of Child Healthy, Royal Hospital, Muscat P.O. Box 1331, Oman.
Background: Hypertension is prevalent in the pediatric population, with estimated rates between 2% and 5%, and its incidence is rising globally. This study offers a single-center analysis of hypertension in children.
Methods: a retrospective chart review was conducted involving children aged 1 month to 13 years diagnosed with hypertension.
Circulating miRNAs and Machine Learning for Lateralizing Primary Aldosteronism.
Hypertension
December 2024
Department of Endocrinology (B.V., G.N., N.S., B.K.S., P.I.), Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Background: Distinguishing between unilateral and bilateral primary aldosteronism, a major cause of secondary hypertension, is crucial due to different treatment approaches. While adrenal venous sampling is the gold standard, its invasiveness, limited availability, and often difficult interpretation pose challenges. This study explores the utility of circulating microRNAs (miRNAs) and machine learning in distinguishing between unilateral and bilateral forms of primary aldosteronism.
View Article and Find Full Text PDF[Secondary hypertension: diagnosis and treatment].
G Ital Cardiol (Rome)
September 2024
Dipartimento di Medicina e Innovazione Tecnologica (DiMIT), Università degli Studi dell'Insubria, Varese - Dipartimento di Medicina e Riabilitazione Cardiopolmonare, Istituti Clinici e di Ricerca Maugeri IRCCS, Tradate (VA).
Article Synopsis
- * In children, causes of secondary hypertension typically include aortic issues or genetic mutations, while in adults, it can stem from conditions like atherosclerosis or hormonal disorders.
- * Secondary hypertension should be suspected in younger patients, those with treatment-resistant or severe hypertension, rapid increases in blood pressure, and patients showing signs of certain endocrine disorders or sleep apnea.
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