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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial.
JMIR Res Protoc
January 2025
Graduate Program of Psychiatry and Behavioral Sciences, Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition emerging in early childhood, characterized by core features such as sociocommunicative deficits and repetitive, rigid behaviors, interests, and activities. In addition to these, disruptive behaviors (DB), including aggression, self-injury, and severe tantrums, are frequently observed in pediatric patients with ASD. The atypical antipsychotics risperidone and aripiprazole, currently the only Food and Drug Administration-approved treatments for severe DB in patients with ASD, often encounter therapeutic failure or intolerance.
View Article and Find Full Text PDFCommunicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis.
Anal Chem
January 2025
Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States.
Non-targeted analysis (NTA) using high-resolution mass spectrometry without defined chemical targets has the potential to expand and improve chemical monitoring in many fields. Despite rapid advancements within the research community, NTA methods and data remain underutilized by many potential beneficiaries. To better understand barriers toward widespread adoption, the Best Practices for Non-Targeted Analysis (BP4NTA) working group conducted focus group meetings and follow-up surveys with scientists (n = 61) from various sectors (e.
View Article and Find Full Text PDFExploring the textural characteristics of foods preferred by Chinese elderly individuals based on IDDSI levels.
PLoS One
January 2025
Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu, China.
Objective: This study aimed to investigate the textural characteristics of foods preferred by elderly Chinese individuals and their suitability based on the International Dysphagia Diet Standardization Initiative (IDDSI) framework. The goal was to provide objective data to support the development of safe and nutritious diets tailored to the swallowing abilities of the elderly.
Methods: A cross-sectional observational study was conducted, using web-scraping technology to identify 26 commonly preferred food ingredients among elderly individuals across seven regions of China.
Prediction of dry matter intake in growing Black Bengal goats using artificial neural networks.
Trop Anim Health Prod
January 2025
Livestock Production and Management Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
Dry matter intake (DMI) determination is essential for effective management of meat goats, especially in optimizing feed utilization and production efficiency. Unfortunately, farmers often face challenges in accurately predicting DMI which leads to wastage of feed and an increase in the cost of production. This investigation aimed to predict DMI in Black Bengal goats by using body weight (BW), body condition score (BCS), average daily gain (ADG), and metabolic body weight (MBW) by applying an artificial neural network (ANN) model.
View Article and Find Full Text PDFand through the pig meat chain in Sardinia: occurrence, antimicrobial resistance and genetic insight.
Ital J Food Saf
December 2024
Department of Veterinary Medicine, University of Sassari.
This study aimed to characterize Salmonella and Yersinia enterocolitica detected in fattening pigs in Sardinia, examining genetic similarity and antimicrobial resistance of isolates from farms and slaughterhouses and evaluating carcass hygiene. Environmental samples were collected from six pig farms, and the same pigs were also sampled at the slaughterhouses. Palatine tonsils, mesenteric lymph nodes, colon content, and carcass surface samples were collected and tested for Salmonella and Y.
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