The aim of this study was to investigate the existence of correlation between the TNM clinical classification, histologic malignancy grading and anatomical location of oral squamous cell carcinoma. A total of 120 oral squamous cell carcinomas were selected from the files of the Dr. Luiz Antonio Hospital (Natal, Rio Grande do Norte, Brazil). Data concerning TNM clinical classification and anatomical location of lesions were obtained. Histologic malignancy grading was carried out following the criteria defined by Wahi22 (1971). Pearson's correlation test was applied for the statistical analysis of data. It revealed a statistically significant correlation (r = 0.2993, p = 0.01) between TNM clinical classification and histologic malignancy grading. It also revealed correlation between TNM classification and the anatomical location of oral squamous cell carcinomas (r = 0.4463, p = 0.01). We concluded that TNM classification presented correlation with histological grading and with the different anatomical locations of oral squamous cell carcinomas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s1517-74912002000300006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunohistochemical Expression of VEGF and Microvessel Density (CD 34) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Original Research.
Asian Pac J Cancer Prev
January 2025
Adhiparasakthi Dental College and Hospital, Melmaruvathur, India.
Background: Angiogenesis, the formation of new blood vessels from preexisting ones via capillary sprouting, is a crucial process in tumor growth and metastasis. As a tumor's angiogenic capacity increases, its microvasculature, measured by micro vessel density (MVD), also increases. This study aims to evaluate the expression of Vascular Endothelial Growth Factor (VEGF) and CD34 in oral epithelial dysplasia and oral squamous cell carcinoma through immunohistochemical methods.
View Article and Find Full Text PDFUse of Oral Rub and Rinse Technique for Oral Cancer Screening: Results from a Community-based Program in an LMIC.
Asian Pac J Cancer Prev
January 2025
Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Division of Molecular Genetics and Cancer, Mangaluru, Karnataka, India.
Background: Oral cancer screening programs can aid in the early identification of potentially malignant oral lesions. The objective of the present study was to evaluate the effectiveness of the Oral Rub and Rinse (ORR) technique as an oral cancer screening tool and to test its potential in detecting genetic alterations in exfoliated cells obtained through ORR.
Methods: The screening programs were conducted in rural Dakshina Kannada and Udupi districts in Karnataka.
HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop.
Cell Biol Toxicol
January 2025
Department of Oral Anatomy and Physiology, Hospital of Stomatology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Jilin University, Changchun, 130021, China.
Novel strategies to disrupt tumor progression have emerged from studying the interactions between tumor cells and tumor-associated macrophages (TAMs). However, the molecular mechanisms of interactions between tumor cells and TAMs underlying oral squamous cell carcinoma (OSCC) progression have not been fully elucidated. This study explored the molecular mechanism of the HSP27/IL-6 axis in OSCC chemoresistance, invasion, and migration.
View Article and Find Full Text PDFSystematic analyses uncover robust salivary microbial signatures and host-microbiome perturbations in oral squamous cell carcinoma.
mSystems
January 2025
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
Unlabelled: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes play a potential role in the pathogenesis of this disease. However, findings from individual studies have been inconsistent, and a comprehensive understanding of OSCC-associated microbiome dysbiosis remains elusive.
View Article and Find Full Text PDFOleanolic acid inhibits aldo-keto reductase family 1 member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines.
J Dent Sci
January 2025
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Background/purpose: Oral squamous cell carcinoma (OSCC) is a common malignancy often associated with poor prognosis due to chemoresistance. In this study, we investigated whether arecoline, a major alkaloid in betel nuts, can stimulate aldo-keto reductase family 1 member B10 (AKR1B10) levels in OSCC, promoting cancer stemness and leading to resistance to cisplatin (CDDP)-based chemotherapy.
Materials And Methods: Gain- and Loss- of AKR1B10 functions were analyzed using WB and q-PCR of OSCC cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!