AI Article Synopsis
- IDO inhibition during pregnancy in mice leads to maternal immune rejection of genetically different (allogeneic) embryos, while not affecting genetically similar (syngeneic) ones.
- Increased risks of pregnancy failure with IDO inhibitors are linked to maternal C3 deposition at the interface between mother and fetus.
- IDO-expressing cells play a role in immune suppression by reducing T-cell responses against tumors, tissue transplants, and fetal tissues.
Article Abstract
Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.
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| http://dx.doi.org/10.1016/s0165-0378(02)00040-2 | DOI Listing |
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