The present study investigated the role of delta-opioid receptors (ORs) in estrogen facilitation of female rat reproductive behavior (lordosis). Infusion of 2 microg of the selective delta-OR agonist [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE), into the third ventricle facilitated lordosis behavior in ovariectomized (OVX) rats injected with estrogen (E) 48 and 24 h before behavioral testing. Pretreatment with the selective delta-OR antagonist naltrindole (NTDL) blocked DPDPE effects on lordosis behavior. Ventricular infusion of NTDL (40 microg) also suppressed lordosis behavior in fully receptive OVX rats primed with both E and progesterone (P). In addition, NTDL blocked lordosis behavior when infused into the ventromedial nucleus of the hypothalamus (VMH) but not into the medial preoptic area (mPOA). Site-specific infusion of DPDPE into the VMH had dose-dependent, dual effects on lordosis behavior. While a very low dose of DPDPE (0.01 microg) facilitated lordosis behavior, a higher dose (1.0 microg) inhibited receptivity in OVX rats primed with E and a low dose (50 microg) of P. We used 3H-DPDPE to measure the density of delta-ORs in OVX rats treated with vehicle or with E by receptor autoradiography. E treatment did not have any effect on the density of DPDPE binding sites in the VMH, mPOA, medial amygdala, or caudate putamen. The behavioral effects of the ligands used in this study suggest that activation of delta-OR in the VMH by endogenous opioids facilitates estrogen-dependent lordosis behavior.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0166-4328(02)00103-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Meta-analysis of minimally invasive transforaminal lumbar interbody fusion versus oblique lumbar interbody fusion for treating lumbar degenerative diseases.
J Orthop Surg Res
December 2024
Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Objective: This study aims to perform a meta-analysis that integrates multiple literature sources to evaluate the clinical efficacy of oblique lumbar interbody fusion (OLIF) versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for treating lumbar degenerative diseases (LDD).
Methods: A systematic search was conducted across various databases, including CNKI, VIP, WANFANG DATA, SinoMed, PubMed, Cochrane Library, Embase, and Web of Science, for clinical comparative studies on OLIF and MIS-TLIF for treating LDD, covering the time frame from the inception of the databases to September 2024. Following PRISMA guidelines, studies were screened, assessed, and data were extracted rigorously.
Imaging observation of intervertebral disc degeneration in patients with old thoracolumbar fracture-related kyphotic deformity.
Sci Rep
December 2024
Affiliated Fuyang People's Hospital of Anhui Medical University, Sanqing Road 501, Fuyang, 236000, Anhui, China.
Old thoracolumbar fracture with kyphosis (OTLFK) often results in low back pain, with intervertebral disc degeneration being a significant contributor. We hypothesized that patients with OTLFK exhibit distinct patterns of disc degeneration compared to those with chronic low back pain without kyphotic deformity. This study aimed to investigate the characteristics of disc degeneration in OTLFK patients and explore its association with sagittal spinal parameters and endplate injury.
View Article and Find Full Text PDFEffects of minipuberty disruption on the expression of sexual behavior in female mice.
Sci Rep
December 2024
Sorbonne Université, CNRS UMR8246, INSERM U1130, Neuroscience Paris Seine - Institut de Biologie Paris Seine, Paris, France.
Sex steroids influence early organization of neural structures involved in expression of sexual behavior. A critical perinatal period during which testosterone surges occur has been identified in male rodents. Data are lacking for females, whose ovarian activity starts later in the postnatal period.
View Article and Find Full Text PDFSpine Kinematics Behavior During the Handstand Posture: A Biplanar Radiographic Analysis.
J Funct Morphol Kinesiol
December 2024
Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers Sciences and Technologies, 75013 Paris, France.
The handstand is an exercise performed in many sports, either for its own sake or as part of physical training. Unlike the upright bipedal standing posture, little is known about the sagittal alignment and balance of the spine during a handstand, which may hinder coaching and reduce the benefits of this exercise if not performed correctly. The purpose of this study was to quantify the sagittal alignment and balance of the spine during a handstand using radiographic images to characterize the strategies employed by the spino-pelvic complex during this posture.
View Article and Find Full Text PDFChange in standing acetabular orientation 2 years postoperatively after surgical correction of adult spinal deformity.
Orthop Traumatol Surg Res
December 2024
Arts et Métiers ParisTech, 151 Boulevard de l'Hôpital, 75013 Paris, France.
Introduction: Although sagittal alignment is known to influence pelvic position, few studies accurately identify the relationship between sagittal alignment and acetabular orientation. We hypothesized that postoperative PT should be correlated with acetabular change in native hips after surgical correction of adult spinal deformity. The objective of this study was therefore to describe the correlation between the change in pelvic tilt and the change in acetabular orientation two years after surgical correction of adult spinal deformity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!