While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128753 | PMC |
| http://dx.doi.org/10.1128/AAC.46.11.3654-3656.2002 | DOI Listing |
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