Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1182/blood-2002-04-1148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mcl-1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent-Induced ER Stress and TRAIL-Induced Apoptosis.
J Cell Biochem
January 2025
Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
We previously reported that ferroptosis interplays with apoptosis through the integration of two independent pathways: the endoplasmic reticulum (ER) stress signaling pathway and the mitochondria-dependent apoptotic signaling pathway. In this study, we investigated a potential gatekeeper molecule, Mcl-1, between the two signal transduction pathways. Morphology studies and cell death analyses confirmed that a combination treatment of ferroptotic agent erastin (ERA) and apoptotic agent TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) synergistically enhances TRAIL-induced apoptosis in human pancreatic adenocarcinoma BxPC3 and human colorectal carcinoma HCT116 cells.
View Article and Find Full Text PDFCorrection: p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.
Oncogene
January 2025
MRC Toxicology Unit, University of Leicester, Leicester, UK.
Corrigendum to "MOTS-c relieves hepatocellular carcinoma resistance to TRAIL-induced apoptosis under hypoxic conditions by activating MEF2A" [Exp. Cell Res., Volume 444, Issue 1, 1 January 2025, 114354].
Exp Cell Res
December 2024
Hypoxia and Health Medicine Research Center, Jilin Medical University, Jilin, 132013, Jilin Province, PR China. Electronic address:
Treatment with TNFα and lipolysis-stimulated lipoprotein receptor (LSR) antibody in the presence of HDAC inhibitors promotes apoptosis in human salivary duct adenocarcinoma.
Tissue Barriers
December 2024
Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo, Japan.
Lipolysis-stimulated lipoprotein receptor (LSR), a lipid metabolism-related factor localized in tricellular tight junctions (tTJs), plays an important role in maintaining the epithelial homeostasis. LSR is highly expressed in well-differentiated cancers, and its expression decreases during malignancy. The LSR antibody inhibits cell growth and promotes apoptosis in some cancers.
View Article and Find Full Text PDFOptimizing autophagy modulation for enhanced TRAIL-mediated therapy: Unveiling the superiority of late-stage inhibition over early-stage inhibition to overcome therapy resistance in cancer.
Basic Clin Pharmacol Toxicol
January 2025
Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, South Korea.
Autophagy is a vital mechanism that eliminates large cytoplasmic components via lysosomal degradation to maintain cellular homeostasis. The role of autophagy in cancer treatment has been studied extensively. Autophagy primarily prevents tumour initiation by maintaining genomic stability and preventing cellular inflammation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!