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Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation.
J Immunol
December 2024
Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus OH.
Article Synopsis
- - The study investigates the connection between CMV infection and Th17 cells in kidney transplant recipients, finding that both factors independently raise the risk of late allograft loss.
- - Researchers observed that CMV-specific Th17 cells were present in blood samples and expanded during CMV reactivation, showing distinct characteristics compared to general Th17 cells.
- - The findings suggest that CMV-induced Th17 cells might play a role in causing inflammation that can lead to damage in transplanted kidneys, highlighting a possible pathway for allograft injury.
Belatacept-related cytomegalovirus infection: Advocacy for tailored immunosuppression based on individual assessment of immune fitness.
Am J Transplant
February 2025
Université de Bordeaux, CNRS, ImmunoConcEpT UMR_5164, INSERM ERL U1303, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Bordeaux, France; Département de Néphrologie, Transplantation, Dialyse et Aphérèse, Hôpital Pellegrin, Bordeaux, France. Electronic address:
Belatacept, a fusion protein combining cytotoxic T-lymphocyte antigen-4 (CTLA-4) and the Fc region of human IgG1, is increasingly used as a calcineurin inhibitor-sparing regimen in patients with chronic graft dysfunction. Older kidney transplant recipients, particularly from expanded criteria donors, may be switched to belatacept due to poor renal recovery. However, late-onset cytomegalovirus (CMV) reactivation is increasingly reported with this treatment, especially in older patients with graft dysfunction.
View Article and Find Full Text PDFCytomegalovirus Retinitis: Clinical Manifestations, Diagnosis and Treatment.
Viruses
September 2024
Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Cytomegalovirus (CMV) retinitis is the most common eye disease associated with CMV infection in immunocompromised individuals. The CMVR may initially be asymptomatic; however, relatively mild vitreous inflammation at the onset may be an important differential point from other diseases in HIV patients. Fundus photography, CD4 T-cell count, and telemedicine could be used to screen and monitor the high-risk population, particularly in resource-limited regions.
View Article and Find Full Text PDFT cell responses and clinical symptoms among infants with congenital cytomegalovirus infection.
JCI Insight
September 2024
Department of Pediatrics, Division of Infectious Diseases, and.
BACKGROUNDCongenital cytomegalovirus (cCMV) infection can cause developmental impairment and sensorineural hearing loss (SNHL). To determine the relationship between immune responses to cCMV infection and neurologic sequelae, T cell responses were compared for their connection to clinical symptoms at birth and neurodevelopmental outcomes.METHODSThirty cCMV-infected and 15 uninfected infants were enrolled in a single-center prospective observational case-control study.
View Article and Find Full Text PDFT-Cell Immune Responses in Newborns and Long-Term Sequelae in Congenital Cytomegalovirus Infection (CYTRIC Study).
J Pediatr
September 2024
Pediatric Infectious Diseases Unit, Department of Pediatric Infectious Diseases, Hospital Universitario 12 de Octubre, RITIP, Madrid, Spain.
Objective: The objective of this study was to assess the role of T-lymphocyte immune responses in newborns with congenital cytomegalovirus (CMV) infection (cCMV) and their potential association with the development of long-term sequelae.
Study Design: A multicenter, prospective study from 2017 to 2022 was conducted across 8 hospitals in Spain. Blood samples were collected within the first month of life from neonates diagnosed with cCMV.
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