Lactic acid bacteria and particularly Lactococcus lactis are widely used for the production of lactic acid in fermented foods. Control of the catabolic rate in L. lactis, i.e., the rate of lactic acid production, appears to be determinant for dairy product quality. While the mechanisms involved in control have not been totally elucidated, they seem to depend upon the strain and the growth conditions. Furthermore, it remains unclear whether the catabolic rate is controlled at the level of transcription, translation or enzyme activity. The recent sequencing of the L. lactis genome has brought novel insights to physiologic studies of the bacteria. This review discusses both genetic information and metabolic studies concerning anaerobic sugar catabolism in L. lactis.
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In Vitro Model
November 2023
Research Institute for Applied Mechanics, Kyushu University, Fukuoka, Japan.
Previously, we have developed a novel porous hydroxyapatite/poly l-lactic-co-caprolactone (HA/PLCL) composite sandwich beam as a new scaffold material for bone regeneration. This work presents the study of bending fracture mechanisms and microdamage of porous hydroxyapatite/poly L-lactic-acid (HA/PLLA) sandwich beam, in comparison to the previous developed HA/PLCL sandwich beam. Both beams were fabricated using the sandwich method in which the single porous composite beams were layered in between two porous polymer layers of their kind.
View Article and Find Full Text PDFPeerJ
January 2025
Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco, Temuco, Chile.
Objective: This study aimed to determine the association between changes in lactate production and levels of physical activity in a group of healthy young adults in response to two squat training protocols.
Material And Methods: Twenty-nine students majoring in Sports Science willingly participated in this study. Participants visited the lab four times within a two-week period, ensuring at least 48 h between visits.
Small
January 2025
INM - Leibniz Institute for New Materials, Saarland University, Campus D2 2, 66123, Saarbrücken, Germany.
Engineered living materials (ELMs) made of bacteria in hydrogels have shown considerable promise for therapeutic applications through controlled and sustained release of complex biopharmaceuticals at low costs and with reduced wastage. While most therapeutic ELMs use E. coli due to its large genetic toolbox, most live biotherapeutic bacteria in development are lactic acid bacteria due to native health benefits they offer.
View Article and Find Full Text PDFJ Cardiothorac Surg
January 2025
Department of Anesthesiology, Zhongda hospital, Southeast University, No. 87 Dingjiaqiao, Nanjing City, 210009, Jiangsu Province, China.
Monitoring perioperative tissue perfusion is crucial in clinical anesthesia to protect organs and ensure patient safety. Indicators like hemodynamic parameters, tissue metabolism, and microcirculation markers are used for assessment. Studies show intraoperative hypotension negatively impacts outcomes, though blood pressure alone may not reflect tissue perfusion accurately.
View Article and Find Full Text PDFBMC Pediatr
January 2025
Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, 272007, Shandong, China.
Purpose: To investigate the clinical features and prognosis of severe central nervous system (CNS) injury in children caused by coronavirus disease 2019 (COVID-19).
Method: We retrospectively studied confirmed pediatric cases of COVID-19 complicated with CNS injury.
Results: Nine patients diagnosed with COVID-19 complicated with severe CNS injury were admitted to the pediatric intensive care unit of the Affiliated Hospital of Jining University from December 1, 2022 to January 12, 2023.
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