Delayed lethal response to Aspergillus fumigatus infection in sarcoma 180 tumor-bearing mice.

FEMS Immunol Med Microbiol

The Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Sendai Aoba-ku, Miyagi, 981-8558 Japan.

Published: October 2002

A longer survival and a decrease in the number of fungal cells in kidneys and brain were observed in groups of mice inoculated with Aspergillus fumigatus conidia 2-3 weeks (especially 3 weeks) after sarcoma 180 tumor transplantation compared to groups of non-tumor-bearing (control) mice inoculated with fungal cells only. The 3-4-week tumor-bearing mice had significantly decreased levels of serum iron and increased levels of unbound iron binding capacity in the serum compared to those of the non-tumor-bearing mice.

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http://dx.doi.org/10.1111/j.1574-695X.2002.tb00611.xDOI Listing

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