The surface layer of archaeobacteria protects cells from extreme environments and, in Methanosarcina, may regulate cell adhesion. We identify three domain types that account for the complete architecture of numerous Methanosarcina surface layer proteins (SLPs). We solve the crystal structure for two of these domains, which correspond to the two N-terminal domains of an M. mazei SLP. One domain displays a unique, highly symmetrical, seven-bladed beta propeller fold, and the other belongs to the polycystic kidney disease (PKD) superfamily fold. The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0969-2126(02)00840-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of saline irrigation on the early mechanical characteristics and microstructure of bone cement.
Sci Rep
December 2024
Student Research Committee, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Very high heat is generated during the polymerization of poly (methyl methacrylate) (PMMA) bone cement, which is used for implant fixation in orthopedic surgery. As such, it has been suggested that irrigating the bone cement layer in the surgical site with a saline solution is a way of cooling the layer. In this study, we aimed to determine the influence of irrigation with a saline solution on the flexural strength and the microstructure of the test specimens of two PMMA bone cement brands: Simplex P and FIX 1.
View Article and Find Full Text PDFMechanical prediction method of strata movement and surface subsidence in backfill-strip mining.
Sci Rep
December 2024
Department of Engineering Management, Hefei College of Finance and Economics, Hefei, 230601, People's Republic of China.
Underground coal excavation has caused a series of geological disasters and environmental problems, especially coal mining subsidence. Backfill-strip mining, which combines the advantages of strip mining and backfill mining, can reduce subsidence and improve the recovery rate of coal. Therefore, predicting the impact of backfill-strip mining on the surface environment and strata structure is essential for the better development of backfill-strip mining technology.
View Article and Find Full Text PDFDevelopment and assessment of a novel single-drive variable angle spraying machine.
Sci Rep
December 2024
School of Mechanical Engineering, Changzhou Institute of Technology, Changzhou, 213032, China.
Traditional sprayers are limited to applying spray mixture solely to the upper surfaces of crops. To overcome this limitation, a variable angle spraying machine (VASM) was designed using a linkage system. This machine enables the adjustment of both the spray position and angle through a single input signal, facilitating multi-directional spraying from the top to the bottom of crops.
View Article and Find Full Text PDFUpdates on the Pathogenesis of Canine Atopic Dermatitis and Feline Atopic Skin Syndrome: Part 2, the Skin Barrier, the Microbiome, and Immune System Dysfunction.
Vet Clin North Am Small Anim Pract
December 2024
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 408 Raymond Stotzer Parkway, College Station, TX 77845, USA. Electronic address:
Alterations in the lipid layer and intercellular corneocyte connections can lead to increased allergen penetration through the skin surface. A normal cutaneous microbiome keeps the opportunistic pathogen Staphylococcus pseudintermedius levels low, but allergic inflammation leads to decreased diversity and increase in S pseudintermedius. Keratinocytes sound the initial allergen alarm via cytokine signaling and promote T-helper 2 (Th-2) inflammation.
View Article and Find Full Text PDFTannic acid coordination assembly enhances the interfacial properties of salted egg white gel particles.
Int J Biol Macromol
December 2024
Cooperative Innovation Center of Industrial Fermentation, Ministry of education & Hubei province, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China. Electronic address:
Tannic acid (TA) has attracted the attention of researchers as a promising organic ligand capable of forming metal-organic coordination networks with various metal ions at interfaces to impact surface properties. In this study, we innovatively reported a self-assembly method for surface decoration by depositing TA/Fe coatings on the surface of desalted duck egg white nanoparticles (DEWN), further studying the oil/water interfacial properties of the modified particles. The results showed that the ratio and concentration of TA to Fe could modulate interfacial properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!