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Weighing up GnRH agonist therapy for endometriosis: outcomes and the treatment paradigm.
Expert Opin Pharmacother
January 2025
Obstetrics and Gynecology Department Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Introduction: Endometriosis is a chronic inflammatory estrogen-dependent disease affecting 10% of women worldwide leading to chronic pelvic pain and infertility which may be treated clinically or surgically.
Areas Covered: Current literaure was reviewed using the keywords 'gonadotropin releasing hormone agonists (GnRHa),' 'endometriosis,' 'infertility' and 'chronic pelvic pain.' Relevant papers prioritizing randomized controlled clinical trials (RCT), systematic reviews, meta-analyses, as well as international guidelines were evaluated.
Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making.
Cell Rep
January 2025
Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address:
Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related parameters, it is unclear whether and how this information is coordinated. To address this question, we performed large-scale single-unit recordings simultaneously across 5 medial/orbital frontal and basal ganglia regions as rats decided whether to pursue varying reward payoffs available at different effort costs.
View Article and Find Full Text PDFPatient Perspective on Robotic-Assisted Total Joint Arthroplasty.
Arthroplast Today
February 2025
Georgetown University School of Medicine, MedStar Georgetown University Hospital, Washington, D.C, USA.
Background: Robotic-assisted total joint arthroplasty (TJA) has gained popularity in recent years. Despite mixed patient and surgeon perceptions, conflicting evidence regarding efficacy and cost-effectiveness in comparison to manual TJA exists. Patients' beliefs surrounding robotic-assisted TJA remain unclear.
View Article and Find Full Text PDFImpact of driver licensing renewal policies on older driver crash involvement and injury rates in 13 states, 2000-2019.
Inj Epidemiol
January 2025
Injury Prevention Research Center, University of Iowa, 145 N Riverside Dr., Iowa City, IA, 52242, USA.
Background: Motor vehicle crashes are the second leading cause of injury death among adults aged 65 and older in the U.S., second only to falls.
View Article and Find Full Text PDFMath-anxious people suffer more in math-related events: The perspective of reward processing on motivated behavior.
Ann N Y Acad Sci
January 2025
School of Psychology, Shenzhen University, Shenzhen, China.
Individuals with high math anxiety (HMA) demonstrate a tendency to avoid math-related tasks, a behavior that perpetuates a detrimental cycle of limited practice, poor performance, increased anxiety, and further avoidance. This study delves into the cognitive and neural bases of math avoidance behavior in HMA through the lens of reward processing. In Experiment 1, participants reported their satisfaction level in response to the reward provided after solving an arithmetic problem.
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