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Unlabelled: Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in , causing cell death in the presence of exogenous guanosine and underscoring the critical importance of GTP homeostasis. To investigate the basis of guanosine toxicity, we performed a genetic selection for spontaneous mutations that suppress this effect, uncovering an unexpected link between GTP synthesis and glycolysis.
View Article and Find Full Text PDFHigh organofluorine concentrations in municipal wastewater affect downstream drinking water supplies for millions of Americans.
Proc Natl Acad Sci U S A
January 2025
Environmental Science & Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02134.
Wastewater receives per- and polyfluoroalkyl substances (PFAS) from diverse consumer and industrial sources, and discharges are known to be a concern for drinking water quality. The PFAS family includes thousands of potential chemical structures containing organofluorine moieties. Exposures to a few well-studied PFAS, mainly perfluoroalkyl acids (PFAA), have been associated with increased risk of many adverse health outcomes, prompting federal drinking water regulations for six compounds in 2024.
View Article and Find Full Text PDFReview of the environmental and health risks of hydraulic fracturing fluids.
Heliyon
January 2025
Department of Civil and Environmental Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Lebanon.
The composition of hydraulic fracturing (HF) fluid poses risks to human health and the environment by impacting drinking water sources. Fracturing fluid recovery rate is highly variable, and the fact that a high percentage of the injected HF fluid is not produced back to the surface in some areas raises questions about its fate and possible migration into aquifers. In this paper, the composition of the HF fluid and related toxicity are described, along with insights about the environmental impact linked with HF fluid, synthesized spill data, main factors affecting the flow-back ratio, and induced seismicity related to HF activities.
View Article and Find Full Text PDFMicroplastics and Dechlorane Plus co-exposure amplifies their impacts on soybean plant.
Environ Pollut
January 2025
Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:
The co-existence of microplastics (MPs) and organic pollutants on agricultural ecosystems pose potential implications for both food safety and environmental integrity. The combined effects of MPs with Dechlorane Plus (DP), a newly listed banned flame retardant, remain unknown. This study explores the biological responses of soybean plants to exposure from polyethylene (PE) and polyvinyl chloride (PVC) MPs and DP.
View Article and Find Full Text PDFA new form of hazardous microparticulate contamination to the marine environment from ships using heavy fuel oil with exhaust gas scrubbers - Characterization and implications for fate, transport and ecotoxicity.
Sci Total Environ
January 2025
Department of Marine Science, University of Gothenburg, 45178 Fiskebäckskil, Sweden.
Aiming to reduce sulfur oxides emission in the atmosphere, the International Maritime Organization developed regulations on shipping that came into effect in 2020. The new rules incentivized many owners to install scrubber systems on thousands of ships. However, the overall environmental implications of scrubbers is a controversial subject, largely due to the release of acids, metals, and chemicals in the oceans and impact on marine life.
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