In the 1980s, people in Sweden frequently responded to moose (Alces alces) found dead or in poor physical condition. The number of moose submitted for routine investigations to the National Veterinary Institute (SVA) increased tenfold and the hunters in Alvsborg County were especially concerned. Later, a complex wasting syndrome was described and reports of moose suffering from the syndrome have been collected since 1991. Today, there is no definitive answer as to the underlying causel(s) of the syndrome, but there are several plausible hypotheses that can be divided into two groups: food-related and host-parasite related. The food-related hypotheses are postulated to have any of the following ultimate causes: acidification/liming, browser density/food production or pollution. Our view is that few of the hypotheses have been critically tested. Most of the hypotheses are supported by some observations, which is to be expected because these are post-hoc attempts to explain these very observations.
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http://dx.doi.org/10.1579/0044-7447-31.5.409 | DOI Listing |
JCO Oncol Pract
January 2025
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Cachexia is a systemic wasting syndrome prevalent in patients with cancer that significantly affects quality of life, health care costs, and therapeutic outcomes. Despite its clinical importance, cachexia is rarely formally diagnosed. This deficiency presents a challenge for effective patient management and care, health care resource allocation, and the advancement of therapeutic approaches.
View Article and Find Full Text PDFJ Clin Med
December 2024
NYU Grossman Long Island School of Medicine, 101 Mineola Blvd., Mineola, NY 11501, USA.
A knowledge gap may exist when attempting to identify the pathogenetic mechanisms resulting in the syndrome of inappropriate antidiuretic hormone (SIADH) or hypotonic hyponatremia. Ectopic secretion of antidiuretic hormone [ADH] is the classic cause of SIADH. But another form of inappropriate secretion of ADH occurs when interleukin 6 is activated.
View Article and Find Full Text PDFNutrients
December 2024
Exercise and Sport Science, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo, Spain.
Creatine monohydrate supplementation is widely used by athletes in high-intensity, power-based sports due to its ability to enhance short-term performance by increasing intramuscular phosphocreatine (PCr) stores, which aid in ATP resynthesis during intense muscle contractions. However, emerging evidence suggests that creatine monohydrate offers benefits beyond athletic performance. This narrative review explores the literature supporting the advantages of creatine supplementation in women, vegans, and clinical populations.
View Article and Find Full Text PDFNutrients
December 2024
Fundación Éxito, Medellín 050044, Colombia.
Background/objectives: Child malnutrition is a critical public health concern that significantly hampers children's physical and mental development and imposes serious economic burdens. The World Health Organization (WHO) estimates that malnutrition is responsible for half of all deaths among children under five, leading to long-term consequences such as lower educational achievement, decreased productivity, and deepened poverty. This study aims to estimate the burden of child malnutrition in Colombia for children up to four years old, assessing both direct and indirect costs from a societal perspective.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Clinical and Biological Sciences, University of Torino, 10043 Turin, Italy.
Background And Aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and mitophagy induction in tumor-bearing animals. While basal mitophagy is required for maintaining muscle mass and quality, excessive mitophagy promotes uncontrolled protein degradation, muscle loss and impaired function.
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