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Machine learning and molecular docking prediction of potential inhibitors against dengue virus.
Front Chem
December 2024
African Society for Bioinformatics and Computational Biology, Cape Town, South Africa.
Introduction: Dengue Fever continues to pose a global threat due to the widespread distribution of its vector mosquitoes, and . While the WHO-approved vaccine, Dengvaxia, and antiviral treatments like Balapiravir and Celgosivir are available, challenges such as drug resistance, reduced efficacy, and high treatment costs persist. This study aims to identify novel potential inhibitors of the Dengue virus (DENV) using an integrative drug discovery approach encompassing machine learning and molecular docking techniques.
View Article and Find Full Text PDFRecent advancements in traditional Chinese medicine for COVID-19 with comorbidities across various systems: a scoping review.
Infect Dis Poverty
December 2024
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Background: Traditional Chinese medicine (TCM) has developed a rich theoretical system and practical experience in fighting to infectious diseases over the past thousands of years, and has played an important role in controlling the spread owing to its unique advantages. In particular, its significant contribution to the prevention and control of Corona Virus Disease 2019 (COVID-19) is widely recognized. COVID-19 infection is mainly non-severe with a favorable overall outcome, but patients with comorbidities tend to have a poor prognosis.
View Article and Find Full Text PDFAdvancing knowledge of One Health in China: lessons for One Health from China's dengue control and prevention programs.
Sci One Health
November 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, Shanghai 200025, China.
Background: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.
Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.
Boosting the efficacy of fungal biocontrol: miRNA339-5p-mediated mosquito immunity regulation.
Pest Manag Sci
December 2024
State Key Laboratory of Green Pesticide, College of Plant Protection, South China Agricultural University, Guangzhou, China.
Article Synopsis
- Aedes mosquitoes spread serious diseases like dengue and zika, leading to a need for eco-friendly solutions due to insecticide resistance and few effective vaccines.
- This study explored the interaction between the fungus Metarhizium anisopliae and Aedes albopictus, finding that the fungal infection boosts the mosquitoes' immune response and activates specific immune genes that help fight off the fungus.
- Researchers discovered a microRNA called miR339-5p that regulates immune genes; using a synthetic version of this microRNA increased the fungus's effectiveness in killing mosquitoes, indicating a potential for genetic modifications to improve mosquito control methods.
Infective endocarditis causing recurrent cerebral infarction, cerebral hemorrhage and septic meningitis: A case report.
Medicine (Baltimore)
November 2024
Department of Neurology, Weifang People's Hospital, Weifang, Shandong, China.
Rationale: We reported a rare case of recurrent cerebral infarction, intracerebral hemorrhage, and purulent meningitis, culminating in the diagnosis of a young patient with infective endocarditis who had been treated in 3 hospitals for a long course of illness for 8 months prior to diagnosis. It aims to enhance clinicians' understanding of the neurological complications caused by infective endocarditis.
Patient Concerns: A 25-year-old male, student, was hospitalized for an 8-hour history of speech impairment and drooling with dysphagia.
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