Plasma phospholipid transfer protein (PLTP) is thought to be involved in the remodeling of high density lipoproteins (HDL), which are atheroprotective. It is also involved in the metabolism of very low density lipoproteins (VLDL). Hence, PLTP is thought to be an important factor in lipoprotein metabolism and the development of atherosclerosis. We have overexpressed PLTP in mice heterozygous for the low density lipoprotein (LDL) receptor, a model for atherosclerosis. We show that increased PLTP activity results in a dose-dependent decrease in HDL, and a moderate stimulation of VLDL secretion (
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1074/jbc.M209128200 | DOI Listing |
Publication Analysis
Top Keywords
phospholipid transfer
8
transfer protein
8
pltp thought
8
density lipoproteins
8
low density
8
increased risk
4
risk atherosclerosis
4
atherosclerosis elevated
4
elevated plasma
4
plasma levels
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!