Introduction: Persons with spinal cord injury (SCI) are generally limited to exercise activities using the relatively smaller, less productive upper extremities with limited benefits as compared with leg exercise training. Functional electrical stimulation (FES) assisted ambulation has previously been demonstrated to allow persons with paraplegia to stand and ambulate limited distances.
Purpose: This study compared the peak physiological responses of persons with paraplegia during FES ambulation and voluntary arm exercise.
Methods: Fifteen subjects (T -T ) previously habituated to FES ambulation, completed peak testing of both arm cranking (AC) and FES walking to the point of exhaustion. The AC tests were performed using a graded incremental protocol to exhaustion in 3-min stages and 10-W power output increments. The FES walking test consisted of successive 10-m walking bouts, each trial progressively increased in pace. Metabolic activity was continuously monitored via open-circuit spirometry with heart rate (HR) determined by a 12-lead electrocardiograph for AC and by direct palpation during FES.
Results: Peak VO(2) did not differ between AC (22.9 +/- 3.8 mL x kg x min(-1)) and FES (22.7 +/- 3.9 mL x kg x min(-1)). FES ambulation elicited significantly greater peak values of HR (191 beats x min(-1) versus 179 beats x min(-1)) and lower peak values of respiratory exchange ratio (1.06 vs 1.12) compared with AC. There were no significant differences in peak values of any other variables.
Conclusion: This study indicates that FES ambulation performance, in persons with paraplegia, elicits similar exercise capacity, as indicated by similar peak oxygen consumption, as voluntary arm exercise.
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http://dx.doi.org/10.1097/00005768-200210000-00004 | DOI Listing |
Eur J Neurol
January 2025
Service de Génétique Médicale, CHU Bordeaux, Bordeaux, France.
Purpose: Heterozygous pathogenic variants in SPAST are known to cause Hereditary Spastic Paraplegia 4 (SPG4), the most common form of HSP, characterized by progressive bilateral lower limbs spasticity with frequent sphincter disorders. However, there are very few descriptions in the literature of patients carrying biallelic variants in SPAST.
Methods: Targeted Sanger sequencing, panel sequencing and exome sequencing were used to identify the genetic causes in 9 patients from 6 unrelated families with symptoms of HSP or infantile neurodegenerative disorder.
Cerebellum
December 2024
Department of Neurology, International University of Health and Welfare Mita Hospital, Mita 1-4-3, Minato-ku, Tokyo, 108-8329, Japan.
Variants in KIF1A are associated with hereditary spastic paraplegia (SPG30), which can manifest in both pure and complex forms. We describe a Japanese family with a novel KIF1A variant presenting with a complex form of SPG30. Patient 1, a 69-year-old woman, experienced progressive gait disturbance due to spastic paraparesis and cerebellar atrophy, and intellectual disability.
View Article and Find Full Text PDFProtein Sci
January 2025
Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
This study focuses on spastic paraplegia type 50 (SPG50), an adapter protein complex 4 deficiency syndrome caused by mutations in the adapter protein complex 4 subunit mu-1 (AP4M1) gene, and on the downstream alterations of the AP4M1 protein. We applied a battery of heterogeneous computational resources, encompassing two in-house tools described here for the first time, to (a) assess the druggability potential of AP4M1, (b) characterize SPG50-associated mutations and their 3D scenario, (c) identify mutation-tailored drug candidates for SPG50, and (d) elucidate their mechanisms of action by means of structural considerations on homology models of the adapter protein complex 4 core. Altogether, the collected results indicate R367Q as the mutation with the most promising potential of being corrected by small-molecule drugs, and the flavonoid rutin as best candidate for this purpose.
View Article and Find Full Text PDFFront Rehabil Sci
December 2024
Department of Statistics, Jahangirnagar University, Dhaka, Bangladesh.
Design: Prospective, cross-sectional study.
Objectives: To determine the functional outcome and home and social integration of people who had spinal cord injury and completed their inpatient rehabilitation.
Setting: Centre for the Rehabilitation of the Paralysed (CRP), Bangladesh.
Pan Afr Med J
December 2024
Infectious Diseases Department, Ibn Al Jazzar University Hospital, Kairouan, Tunisia.
Pneumococcal meningitis is the most severe bacterial meningitis rarely complicated by acute myelitis. We report a case of a 54-year-old female who presented with pneumococcal meningoencephalitis. After eight days of hospitalization, the patient presented a sudden onset of bilateral lower leg weakness and bladder and bowel sphincter dysfunction.
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