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Early prediction of severe retinopathy of prematurity requiring laser treatment using physiological data.
Pediatr Res
August 2023
Department of Paediatrics, University of Oxford, Oxford, UK.
Background: Early risk stratification for developing retinopathy of prematurity (ROP) is essential for tailoring screening strategies and preventing abnormal retinal development. This study aims to examine the ability of physiological data during the first postnatal month to distinguish preterm infants with and without ROP requiring laser treatment.
Methods: In this cohort study, preterm infants with a gestational age <32 weeks and/or birth weight <1500 g, who were screened for ROP were included.
Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.
Front Endocrinol (Lausanne)
March 2019
Division of Obstetrics and Gynecology, Department of Women-Children-Teenagers, University Hospitals Geneva, Geneva, Switzerland.
The environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate the growth of the fetus and its metabolism during pregnancy by controlling the supply of nutrients crossing the placenta. In addition to fetal synthesis, hormones regulating fetal growth are also expressed and regulated in the placenta, and they play a key role in the vulnerability of the developing brain and its maturation.
View Article and Find Full Text PDFProtective role of glucocorticosteroid prior to endotoxin exposure in cultured neonatal type II alveolar epithelial cells.
Pulm Pharmacol Ther
October 2018
Laboratory of Pediatric Respiratory and Intensive Care Medicine, Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China. Electronic address:
Background: Dexamethasone (DEX) is widely used for antenatal lung maturation and has been investigated to prevent premature lung injury by inhibiting postnatal inflammation. Its pharmacological mechanisms in the treatment of bacterial infection-induced injury of neonatal lung parenchymal cells remain to be clarified. We hypothesized that DEX pretreatment may attenuate endotoxin-induced growth suppression and regulate cytokine mRNA expression in cultured neonatal type II alveolar epithelial cells (AEC-II).
View Article and Find Full Text PDFCan the preterm lung recover from perinatal stress?
Mol Cell Pediatr
December 2016
Neonatology, Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands.
After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfere with fetal and neonatal lung development. Prenatal insults like chorioamnionitis and prenatal interventions like maternal glucocorticosteroids interact but might also determine the preterm baby's lung response to postnatal interventions ("second hit") like supplementation of oxygen and drug therapy.
View Article and Find Full Text PDFInfluence of Antenatal Glucocorticosteroid Exposure on Osteoprotegerin and Receptor Activator of Nuclear Factor x03BA;B Ligand Levels in Newborn Infants.
Horm Res Paediatr
April 2017
Department of Paediatrics, University of Patras, Medical School, Patras, Greece.
Background/aims: The physiologic relevance of osteoprotegerin (OPG) and the receptor activator of nuclear factor x03BA;B ligand (RANKL) in the preterm neonate is unknown. The aim of this study was to examine the effects of prematurity on OPG and RANKL concentrations at birth and to investigate in particular whether antenatal corticosteroid (ACS) exposure affects serum OPG and RANKL levels in premature neonates.
Methods: Quantitative determination (enzyme immunoassay) of serum OPG and RANKL at 24 postnatal hours was performed in 47 healthy term neonates, 43 preterm newborns not exposed to ACS, and 55 preterm infants exposed to ACS.
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