AI Article Synopsis
- The viral infectivity factor (Vif) of HIV-1 helps the virus evade an antiviral response that is only present in nonpermissive cells.
- Through a yeast two-hybrid screening of a human lymphocyte library, researchers discovered several potential partners of Vif, including a protein called Sp140.
- Sp140 was consistently found in all tested NP cell lines and was shown to partially disperse from the nucleus into the cytoplasm when HIV-1 infects the cells, suggesting its role in a response to HIV-1 that might interact with the pathway targeting HIV-1 without Vif.
Article Abstract
The viral infectivity factor (Vif) of human immunodeficiency virus type 1 (HIV-1) neutralizes an unidentified antiviral pathway that occurs only in nonpermissive (NP) cells. Using a yeast two-hybrid screen of a human lymphocyte cDNA library, we identified several potential Vif partners. One, the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif. Our results implicate Sp140 in a response to HIV-1 that may be related to or coordinated with the pathway that inactivates HIV-1 lacking vif.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136615 | PMC |
| http://dx.doi.org/10.1128/jvi.76.21.11133-11138.2002 | DOI Listing |
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