Objectives: To describe social and family support, drug use, and knowledge, practices and attitudes related to AIDS and its prevention among male teenagers.
Methods: Participants were 275 male teenagers interned in a youth detention center (FEBEM - State Foundation for Juvenile Well-Being) in São Paulo, Brazil. There were two segments. In segment 1, semi-structured interviews with 20 detainees took place. In segment 2, close-end self-administered questionnaires covering sociodemographic data, criminal records, sexual practices, drug use, attitudes, knowledge and AIDS-related practices were applied.
Results: Ninety percent of the detainees lived previously with their families. All of them had attended public schools, although 61% had already dropped out. Twelve percent had never used drugs, and 5.5% were intravenous drug users. Most (98%) were sexually active; 35% had had more than 15 sexual partners, 8% had homosexual experiences (inside or outside the center), 12% had exchanged sex for material return and 22% were fathers. Many said that getting HIV infected "that's life " and that they face greater risks in their lives, such as surviving on the streets. They think condoms are easily broken (83%) and interfere with sex (58%); 72% had used condoms but only 9% used them with all their partners.
Conclusions: These teenagers have a very high risk of HIV infection. It is necessary to integrate AIDS prevention programs to their life ills and related problems such as racism, expectations for the future, criminality, drug use, basic rights including sexual and reproductive rights, and show them there are alternatives other than exposing themselves to HIV infection or dying as criminals.
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Cureus
December 2024
Department of Neurosurgery, Hurley Medical Center, Flint, USA.
Iodoform, a halogenated organic compound, has been a cornerstone in surgical practice due to its potent antiseptic and antimicrobial properties. This comprehensive review examines the historical evolution, mechanism of action, clinical applications, and safety profile of iodoform across various surgical disciplines. Historically significant formulations like Whitehead's varnish and bismuth iodoform paraffin paste (BIPP) demonstrated remarkable efficacy in wound healing during the late 19th and early 20th centuries.
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Biomedical Research Institute of Southern California, Oceanside, CA, United States.
Interferon types-I/II (IFN-αβ/γ) secretions are well-established antiviral host defenses. The human immunodeficiency virus (HIV) particles are known to prevail following targeted cellular interferon secretion. CD4 T-lymphocytes are the primary receptor targets for HIV entry, but the virus has been observed to hide (be latent) successfully in these cells through an alternate entry route via interactions with LFA1.
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January 2025
Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.
The increasing number of people living with HIV in Korea has prompted interest in using the national surveillance system as a database for studying their health. To investigate the relationships between sociodemographic and epidemiological characteristics and mortality rates, a nationwide retrospective cohort was formed by integrating surveillance data with the Cause of Death Statistics from Statistics Korea. This integration included incidence reports, epidemiological investigations, and death reports from the surveillance data, enriched with detailed mortality information from the Cause of Death data.
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Human Sciences Research Council, Pretoria, South Africa.
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View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:
The COVID-19 pandemic has underscored the urgent need for antiviral agents capable of targeting a broad range of coronaviruses, including emerging variants of SARS-CoV-2. While vaccines have been pivotal, the search for drugs that can prevent viral entry into host cells remains crucial, especially against evolving viral forms and other coronaviruses. In this study, we investigated natural products as a source of antiviral agents, focusing on their potential to block the spike protein's receptor-binding domain (RBD).
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