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Prototype of AI-powered assistance system for digitalisation of manual waste sorting.
Waste Manag
January 2025
Chair of Waste Processing Technology and Waste Management, Montanuniversitaet Leoben, Leoben, Austria. Electronic address:
Global waste generation is projected to reach 3.40 billion tons by 2050, necessitating improved waste sorting for effective recycling and progress toward a circular economy. Achieving this transformation requires higher sorting intensity through intensified processes, increased efficiency, and enhanced yield.
View Article and Find Full Text PDFUse of Antibiotics in Companion Animals from 133 German Practices from 2018 to 2023.
Antibiotics (Basel)
January 2025
Institute of Pharmacology and Toxicology, Freie Universität Berlin, 14195 Berlin, Germany.
: While antibiotic usage in farm animals has been systematically monitored and reduced in many countries, including Germany, data on companion animals such as dogs and cats remain scarce. To address this gap, a study was conducted in Germany to analyze patterns of antibiotic use in dogs and cats. : Antibiotic usage data were obtained from debevet, a cloud-based veterinary practice management software based in Berlin, Germany.
View Article and Find Full Text PDFUse of alternatives to animal testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA partners' forum.
Regul Toxicol Pharmacol
January 2025
Corteva Agriscience, Zuid-Oostsingel 24D, Bergen op Zoom, 4611 BB, the Netherlands.
Environmental Safety Assessments (ESA) are mandatory for several regulatory purposes and are an important component of stewardship/sustainability initiatives. Fish testing is used for assessing chemical toxicity and bioaccumulation potential; amphibians are included in some jurisdictions and their use is increasing to assess endocrine disruption. Alternative methods are becoming more available, covering the principles of the 3Rs (i.
View Article and Find Full Text PDFMapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection.
NIHR Open Res
January 2025
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, England, L69 7BE, UK.
Background: PROTECT ( Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy) has brought together a team of researchers to design a platform trial to rapidly evaluate and adopt into care multiple diagnostic technologies, bringing immediate benefit to patients. Rapid diagnostic tests will be used to identify patients at risk of deterioration from severe infection, before they become critically unwell. The platform will assess their comparative clinical effectiveness and cost-effectiveness relative to current standard of care.
View Article and Find Full Text PDFMultiplex digital PCR enables sensitive detection of resistance to BTK inhibitors.
Ann Hematol
January 2025
Service de Thérapie Cellulaire et d'Hématologie Clinique, CHU Estaing, Clermont-Ferrand, France.
The advent of BTK inhibitors has been transformative in the management of patients with chronic lymphocytic leukemia or other B-cell lymphoproliferative disorders. However, emergence of BTK or PLCG2 mutations lead to resistance to these compounds and are now a growing concern in clinical practice. Assessing BTK mutations is now becoming a priority to guide the therapeutic decision at further relapse.
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