Background: A previous study demonstrated a 40% higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated.
Method: Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons.
Results: The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35% greater than the rate in siblings of singletons. The result was statistically significant (p = 0.04). The rate in siblings of monozygotic twins was not increased.
Conclusion: The results are in accordance with a theory of a linkage between genes influencing the rate of dizygotic twinning and genes influencing the threshold for developing schizophrenia.
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- A study examined fertility traits and family histories of dizygotic (DZ) twins among 972 Nigerian mothers of DZ twins and 525 controls, revealing significant genetic influences on twinning in the Nigerian population.
- The research found that mothers of DZ twins (MoDZT) had an average of 4.0 pairs of twins in their relatives, significantly higher than the 0.5 pairs found in the control group, who also rarely had twins in their families.
- MoDZT also had earlier childbirth ages and higher numbers of children compared to controls, suggesting enhanced fertility; furthermore, mothers with multiple sets of twins had even more twins in their families and had their first twins at a younger age, indicating a potential genetic predis
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