This study investigated computed radiography (CR) image processing to determine whether variation exists within and among CR imaging plate readers. Photostimulable imaging plates were exposed using a phantom test tool and processed in 4 CR readers located in diverse settings in an urban academic medical center. Research results indicate daily variation of S-numbers within individual CR readers did not exceed tolerance limits, although over the 3-week study period, evidence of S-number variation within individual CR readers was mixed. In addition, S-number variability among multiple CR readers was found to be statistically significant. Although the cause of the variability remains unknown, evidence of variability among multiple CR readers indicates a need for systematic quality control.

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