We deal in this paper with the concept of health smart home (HSH) designed to follow dependent people at home in order to avoid the hospitalisation, limiting hospital sojourns to short acute care or fast specific diagnostic investigations. For elderly people the project of such a HSH has been called AISLE (Apartment with Intelligent Sensors for Longevity Effectiveness). For this purpose, system having three levels of automatic measuring (1) the circadian activity, (2) the vegetative state, and (3) some state variables specific of certain organs involved in precise diseases, has been developed within the framework of a 'Health Integrated Smart Home Information System' (HIS2). HIS2 is an experimental platform for technologic development and clinical evaluation, in order to ensure the medical security and quality of life for patients who need home based medical monitoring. Location sensors are placed in each room of the HIS2, allowing the monitoring of patient's successive daily activity phases within the patient's home environment. We proceed with a sampling in an hourly schedule to detect weak variations of the nycthemeral rhythms. Based on numerous measurements, we establish a mean value with confidence limits of activity variables in normal behaviour permitting to detect for example a sudden abnormal event (like a fall) as well as a chronic pathologic activity (like a pollakiuria), allowing us to define a canonical domain within which the patient's activity is qualified to be 'predictable'. Alerts are set off if the patient's activity deviates from a predictable canonical domain. Moreover, we can follow the cardio-respiratory state by measuring the intensity of the respiratory sinusal arrhythmia in order to quantify the integrity of the bulbar vegetative system, and we finally propose to carefully watch abnormal symptoms like arterial pressure or presence of plasma proteins in the expired air flow for early detecting respectively hypertension or pulmonary oedema.
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http://dx.doi.org/10.1016/s1631-0691(02)01480-4 | DOI Listing |
Clinicoecon Outcomes Res
January 2025
Department of Orthopaedic Surgery, UC San Francisco, San Francisco, CA, 94143-0728, USA.
Background/context: Chronic low back pain (CLBP) is a significant US healthcare burden with millions of lumbar spine procedures annually. Diagnostic tests are essential to guide treatment but provocative discography (PD), the most common diagnostic procedure, is without robust evidence of its value. A non-invasive alternative using Magnetic Resonance Spectroscopy (MRS) offers a potential solution.
View Article and Find Full Text PDFJSES Rev Rep Tech
February 2025
Rowley Bristow Orthopaedic Unit, Chertsey, UK.
Background: Surgical intervention for lateral epicondylitis remains a controversial topic, with its purpose being debated. Recent guidelines have concluded no benefit from surgery when compared to conservative management.
Methods: An electronic database search of Ovid Medline via PubMed, EMBASE, and the Web of Science was performed to understand the published literature further.
J Mater Chem B
January 2025
Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, P. R. China.
Drug delivery for epilepsy treatment faces enormous challenges, where the sole focus on enhancing the ability of drugs to penetrate the blood-brain barrier (BBB) through ligand modification is insufficient because of the absence of seizure-specific drug accumulation. In this study, an amphipathic drug carrier with a glucose transporter (GLUT)-targeting capability was synthesised by conjugating 2-deoxy-2-amino-D-glucose (2-DG) to the model carrier DSPE-PEG. A 2-DG-modified nano drug delivery system (NDDS) possessing robust stability and favourable biocompatibility was then fabricated using the nanoprecipitation method.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia.
Polycyclic aromatic compounds (PACs) are pervasive environmental contaminants derived from diverse sources including pyrogenic (e.g., combustion processes), petrogenic (e.
View Article and Find Full Text PDFAquat Toxicol
January 2025
School of Public Health, Chongqing Medical University, Chongqing, 401331, China. Electronic address:
Nano-plastics (NPs) and heavy metals have attracted growing scientific attention because of both pollutants' wide distribution and ecotoxicity. However, the long-term combined toxicity of NPs and mercury (Hg) on planktonic copepods, a crucial presence in marine environments, is unknown. Here, our study aimed to investigate the multigenerational phenotypic responses of the planktonic copepod Pseudodiaptomus annandalei to polystyrene NPs (about 50 nm) and Hg (alone or combined) at environmentally realistic concentrations (23 μg/L for NPs and 1 μg/L for Hg), and the underlying molecular mechanisms were explored.
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