AI Article Synopsis
- Previous research indicated that vitamin E reduces autoantibodies related to oxidized lipid-protein complexes and inhibits tumor promotion in liver cells.
- A new human cytokine array system was developed to analyze the effects of vitamin E on cytokine expression, revealing that vitamin E supplementation significantly lowers levels of certain cytokines, particularly MCP-1.
- This study is the first to report that vitamin E supplementation can down-regulate MCP-1 expression in live subjects, suggesting its critical role as an antioxidant.
Article Abstract
Previously, we demonstrated that vitamin E supplementation decreases autoantibodies to oxidized lipid-protein complexes (J. Med. Food 1 (2000) 247). Utilizing an in vitro modeling system, we also demonstrated that vitamin E blocks the tumor promotion process in liver epithelial cells (Carcinogenesis 20 (1999) 485 and Mol. Carcinog. 30 (2001) 209). To investigate the molecular mechanisms of vitamin E function, we developed a human cytokine array system that is capable of detecting the expression of 35 cytokines simultaneously. Using this new technology, we analyzed the potential vitamin E-regulated cytokines in vitamin E supplementation individuals. The cytokine arrays showed that expression of several cytokines, particularly monocyte chemoattractant protein-1 (MCP-1), was profoundly reduced in vitamin E supplementation individuals. Moreover, addition of vitamin E to several cultured cells significantly down-regulated the expression of MCP-1. Our results suggested that MCP-1 may be one of the most important targets of antioxidant vitamin E. To the best of our knowledge, this is the first report describing the down-regulation of MCP-1 in vitamin E supplementation in vivo.
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| http://dx.doi.org/10.1016/s0304-3835(02)00346-4 | DOI Listing |
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