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Alopecia Areata Is Associated with an Increased Risk for Prediabetes and Obesity: A Nationwide Case-Control Study.
J Pers Med
January 2025
Maccabi Health Services, Tel-Aviv 6812509, Israel.
Alopecia areata (AA) is a non-scarring inflammatory hair loss condition associated with various immune-mediated comorbidities. Prediabetes, characterized by elevated blood glucose levels not yet high enough to be classified as diabetes, significantly increases the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular complications. The associations between AA obesity and prediabetes have long been investigated in an attempt to identify preventable risk factors, yet the literature is relatively scarce and inconclusive.
View Article and Find Full Text PDFBiologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review.
Indian Dermatol Online J
December 2024
Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
Background: Inflammatory dermatological conditions, including psoriasis, lichen planus, eczema, and alopecia areata, are frequently accompanied by nail findings and can have a significant impact on quality of life. Biologic and small-molecule medications have been approved over the past several decades in treating patients with these inflammatory nail disorders. They may be used in conjunction with longstanding mainstays of treatment (topical and intralesional corticosteroids, topical vitamin D3 analogs).
View Article and Find Full Text PDFUnexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights.
Cureus
December 2024
Department of Dermatology and Venereology, Zhongnan Hospital of Wuhan University, Wuhan, CHN.
Alopecia universalis (AU) is a severe form of alopecia areata characterized by the complete loss of scalp and body hair. While Janus kinase (JAK) inhibitors like baricitinib have shown promise in promoting hair regrowth in severe cases of AU, unexpected side effects, such as hair depigmentation, have not been widely reported. We present the case of a young male with AU who experienced progressive and extensive whitening of his scalp and body hair following treatment with baricitinib.
View Article and Find Full Text PDFEyelash trichomegaly complicating pembrolizumab for colorectal cancer.
J Oncol Pharm Pract
January 2025
Department of Oncology, Evaggelismos General Hospital, Athens, Greece.
Introduction: Pembrolizumab is an immune checkpoint inhibitor widely administered for the treatment of various malignancies. Despite its effectiveness, its distinctive mechanism of action may lead to immune-related adverse events, most frequently affecting cutaneous tissues. Hair-related adverse events, although uncommon, include conditions such as alopecia areata and alterations in hair texture or type.
View Article and Find Full Text PDFDiscovery of Orally Available Prodrugs of Itaconate and Derivatives.
J Med Chem
January 2025
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Prague 160 00, Czech Republic.
Itaconate, an endogenous immunomodulator from the tricarboxylic acid (TCA) cycle, shows therapeutic effects in various disease models, but is highly polar with poor cellular permeability. We previously reported a novel, topical itaconate derivative, SCD-153, for the treatment of alopecia areata. Here, we present the discovery of orally available itaconate derivatives for systemic and skin disorders.
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