The paper presents some data on the structure of the systole of the right ventricle obtained by means of kinetocardiography in 280 sportsmen, aged 12-14 years, with different functional states of their organisms (non-trained, poorly and well-trained, with chronic overstraining of the heart), as well as some data on the level of the systolic pressure in the pulmonary circulation system (by the Buzstin method) at rest and during the restorative period after exercises (test of the Leningrad Institute of Physical Culture, bycycle tests). The more the organism is trained, the more distinct the stages ofthe syndrome of regulated myocardial hypodynamia were found to be, a moderate hyperfunctionof the heart is noted during physical exercises that is accompanied by slight elevations of the pressure in the pulmonary system. In cases of chronic cardiac overstraining myocardial hypodynamia, stage I--II, was found, pressure elevation in the pulmonary circulation system -- in 21.4% of the examined persons at rest, its sharp elevation after exercises (up to 78.6 mm Hg) and prolongation of the restorative period. The obtained data demonstrate the perfection of the function of the right ventricle and of the pulmonary circulation under systematic training in the adolescents, and their deterioration in cases of chronic overstraining of the heart.
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Biomedicines
December 2024
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Susceptibility to and severity of pulmonary infections increase with ethanol consumption. We have previously shown that ethanol-induced changes in the gut microbiome disrupt gut homeostasis, allowing for the translocation of proinflammatory mediators into the circulation and eliciting an immune response in the lung. Additionally, targeting the gut with butyrate supplementation not only rescues ethanol-induced disruptions to gut health but also reverses aspects of immune dysregulation in the lungs.
View Article and Find Full Text PDFBiomedicines
November 2024
Pharmacovigilance Center, Information and Methodological Center for Expert Evaluation, Record and Analysis of Circulation of Medical Products Under the Federal Service for Surveillance in Healthcare, 4-1 Slavyanskaya Square, 109074 Moscow, Russia.
Background/objectives: Pulmonary fibrosis (PF) results in a progressive decline of lung function due to scarring. Drugs are among the most common causes of PF. The objective of our study was to reveal the structure of drugs involved in PF development.
View Article and Find Full Text PDFBackground: Pulmonary arterial hypertension (PAH) is a rare but severe and life-threatening condition that primarily affects the pulmonary blood vessels and the right ventricle of the heart. The limited availability of human tissue for research ~most of which represents only end-stage disease~ has led to a reliance on preclinical animal models. However, these models often fail to capture the heterogeneity and complexity of the human condition.
View Article and Find Full Text PDFAnn Noninvasive Electrocardiol
January 2025
Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Background: Electrocardiograms (EKGs) are routinely performed in pregnant patients with pre-existing cardiovascular disease. However, in pregnant patients with congenital heart disease (CHD), EKG changes during gestation have not been explored.
Methods: We performed a retrospective study of pregnant patients with CHD enrolled in the STORCC initiative.
Eur Heart J Cardiovasc Imaging
January 2025
Department of Radiology, UZ Leuven, Leuven, Belgium.
Aims: Atrial septal defect (ASD) and partial abnormal pulmonary venous connection (PAPVC) are noncyanotic congenital heart defects (CHD) that produce a left-to-right shunt. This single-center retrospective study aimed to assess the hemodynamic impact of isolated ASD, isolated PAPVC, and ASD-associated PAPVC using cardiovascular magnetic resonance (CMR).
Methods And Results: From our CMR registry (2002-2024), 110 patients were included: isolated ASD (n=64), isolated PAPVC (n=18), ASD-associated PAPVC (n=28, mostly sinus venosus septal defects).
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