New 3-benzisothiazolyl and 3-benzisoxazolylpiperazine derivatives were synthesised and their 5-HT(1A), 5-HT(2A) and D(2) receptor binding affinities evaluated. The compounds displayed high affinity for the 5-HT(2A) receptor combined with moderate to low 5-HT(1A) and D(2) affinities. Two of them, 18 and 25, have been selected for further pharmacological studies to be evaluated as potential atypical antipsychotics.
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| http://dx.doi.org/10.1016/s0223-5234(02)01391-0 | DOI Listing |
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