The content of 10 trace elements was studied by employing the neutron-activation method and the lead level determined through the spectral analysis in the whole blood, aorta, the heart muscle, liver, intesties (small and large), in the pancreas, adrenal glands, the spleen, lungs of accident victims, among whom 87 were practically healthy and 91 had atherosclerosis. The latter demonstrated in a number of organs (especially in the aorta and liver) a reduction in the content, which increased with age and intensity of atherosclerotic changes, of nickel, manganese, zinc, cobalt, vanadium and iron and rise in the lead, gallium, copper, bismuth and bromine level. The disclosed data bear witness to a definite part played by a number of trace elements in the atherogenesis.
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Environ Sci Technol
January 2025
Geomicrobiology, Department of Geosciences, University of Tübingen, 72076 Tübingen, Germany.
Iron(III) (oxyhydr)oxide minerals with varying particle sizes commonly coexist in natural environments and are susceptible to both chemical and microbial reduction, affecting the fate and mobility of trace elements, nutrients, and pollutants. The size-dependent reduction behavior of iron (oxyhydr)oxides in single and mixed mineral systems remains poorly understood. In this study, we used microbial and mediated electrochemical reduction approaches to investigate the reduction kinetics and extents of goethite and hematite.
View Article and Find Full Text PDFBiopolymers
March 2025
Department of Chemistry, Bose Institute, Kolkata, India.
The stability of α-crystallin, the major protein of the mammalian eye lens and a molecular chaperone, is one of the most crucial factors for its survival and function. The chaperone-like activity and stability of α-crystallin dramatically increased in the presence of Zn. Each subunit of α-crystallin could bind multiple zinc atoms through inter-subunit bridging and cause enhanced stability.
View Article and Find Full Text PDFFront Immunol
January 2025
Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Natural killer (NK) cells are innate immune cells that play a crucial role as a first line of defense against viral infections and tumor development. Iron is an essential nutrient for immune cells, but it can also pose biochemical risks such as the production of reactive oxygen species. The importance of iron for the NK cell function has gained increasing recognition.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.
Methods: To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.
Alzheimers Dement
January 2025
Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
Introduction: The link between overload brain iron and transcriptional/cellular signatures in Alzheimer's disease (AD) remains inconclusive.
Methods: Iron deposition in 41 cortical and subcortical regions of 30 AD patients and 26 healthy controls (HCs) was measured using quantitative susceptibility mapping (QSM). The expression of 15,633 genes was estimated in the same regions using transcriptomic data from the Allen Human Brain Atlas (AHBA).
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