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Pedestrians' Interaction with eHMI-equipped Autonomous Vehicles: A Bibliometric Analysis and Systematic Review.
Accid Anal Prev
January 2025
Department of Systems Engineering, City University of Hong Kong, Hong Kong, China; Shenzhen Research Institute, City University of Hong Kong, Shenzhen, China.
Autonomous vehicles (AVs) should prioritise pedestrian safety in a traffic accident. External human-machine interfaces (eHMIs), which enhance communication through visual and auditory signals, become essential as AVs become prevalent. This study aimed to investigate the current state of research on eHMIs, with a specific focus on pedestrian interactions with eHMI-equipped AVs.
View Article and Find Full Text PDFModified calculation of the IIEF6-a more accurate assessment of erectile function in middle-aged men.
J Sex Med
January 2025
Department of Urology, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, Munich 81675, Germany.
Background: The Erectile Function Domain of the International Index of Erectile Function (IIEF6) is inaccurate in assessing erectile function in men who are not practicing sexual intercourse. Improvement through a modification was recently tested on patients after radical prostatectomy. This study examines the application of this modification in a population-based cohort of middle-aged men.
View Article and Find Full Text PDFPreclinical studies of natural flavonoids in inflammatory bowel disease based on macrophages: a systematic review with meta-analysis and network pharmacology.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Pharmacy School, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Flavonoid is a category of bioactive polyphenolic compounds that are extensively distributed in plants with specific pharmacological properties, such as anti-inflammatory and anti-oxidant. Importantly, natural flavonoids have shown the protected function on the dextran sulfate sodium (DSS)-induced colitis in animals and lipopolysaccharides (LPS)-induced inflammatory response in macrophages. The purpose of this systematic review is to explore the efficacy of natural flavonoids in animal models of IBD (inflammatory bowel disease) and potential mechanisms in macrophages by meta-analysis and network pharmacology in preclinical studies.
View Article and Find Full Text PDFNanotechnology-based drug delivery platforms for erectile dysfunction: addressing efficacy, safety, and bioavailability concerns.
Pharm Dev Technol
November 2024
Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India.
Article Synopsis
- Erectile dysfunction (ED) is a complex sexual disorder influenced by physical, relational, and psychological factors, often leading to health issues like depression and anxiety due to its impact on sexual performance.
- Traditional treatment methods, including lifestyle changes and medications, have limitations in safety and effectiveness, prompting interest in new methods, such as nanomedicine, for managing ED.
- Nanotechnology offers advanced drug delivery systems that improve treatment outcomes by ensuring targeted delivery and minimizing side effects, making it a promising area for future clinical applications in ED management.
Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis.
Immunol Rev
October 2024
Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Inflammasomes are multi-protein complexes that assemble within the cytoplasm of mammalian cells in response to pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), driving the secretion of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. The best-characterized inflammasome complexes are the NLRP3, NAIP-NLRC4, NLRP1, AIM2, and Pyrin canonical caspase-1-containing inflammasomes, and the caspase-11 non-canonical inflammasome. Newer inflammasome sensor proteins have been identified, including NLRP6, NLRP7, NLRP9, NLRP10, NLRP11, NLRP12, CARD8, and MxA.
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