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A qualitative systematic review of umbilical cord care practices in Nigeria.
BMC Pediatr
January 2025
Department of Public Health, Federal University of Technology Owerri, Owerri, Imo State, Nigeria.
Background: Umbilical cord care is an important aspect of newborn health, and different practices exist around the world, often influenced by cultural, healthcare infrastructure, and socioeconomic factors. The objective of this systematic review is to synthesize current literature on umbilical cord care practices in Nigeria, with an emphasis on the impact of cultural beliefs, healthcare infrastructure, and socioeconomic factors.
Methods: A comprehensive search for literature was performed across PubMED, MEDLINE and Google scholar for studies published between 2010 and 2023.
Genome-Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours.
Cell Prolif
January 2025
NewStem LTD, Jerusalem, Israel.
Synthetic lethality is defined as a type of genetic interaction where the combination of two genetic events results in cell death, whereas each of them separately does not. Synthetic lethality can be a useful tool in personalised oncology. MLH1 is a cancer-related gene that has a central role in DNA mismatch-repair and TP53 is the most frequently mutated gene in cancer.
View Article and Find Full Text PDFA simple inland culture system provides insights into ascidian post-embryonic developmental physiology.
Open Biol
January 2025
Michael Sars Centre, University of Bergen, Bergen, Norway.
Maintenance and breeding of experimental organisms are fundamental to life sciences, but both initial and running costs, and hands-on zootechnical demands can be challenging for many laboratories. Here, we first aimed to further develop a simple protocol for reliable inland culture of tunicate model species of the genus. We cultured both and in controlled experimental conditions, with a focus on dietary variables, and quantified growth and maturation parameters.
View Article and Find Full Text PDFAdenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition.
J Physiol
January 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
The permeability transition (PT) is a permeability increase of the mitochondrial inner membrane causing mitochondrial swelling in response to matrix Ca. The PT is mediated by regulated channel(s), the PT pore(s) (PTP), which can be generated by at least two components, adenine nucleotide translocator (ANT) and ATP synthase. Whether these provide independent permeation pathways remains to be established.
View Article and Find Full Text PDFDifferential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair.
Bone Res
January 2025
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
The cranial mesenchyme, originating from both neural crest and mesoderm, imparts remarkable regional specificity and complexity to postnatal calvarial tissue. While the distinct embryonic origins of the superior and dura periosteum of the cranial parietal bone have been described, the extent of their respective contributions to bone and vessel formation during adult bone defect repair remains superficially explored. Utilizing transgenic mouse models in conjunction with high-resolution multiphoton laser scanning microscopy (MPLSM), we have separately evaluated bone and vessel formation in the superior and dura periosteum before and after injury, as well as following intermittent treatment of recombinant peptide of human parathyroid hormone (rhPTH), Teriparatide.
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