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Management of Endometriosis-Related Pain: Comparing the Effectiveness of Hormonal Therapy, Surgical Interventions, and Complementary Therapies.
Cureus
December 2024
Obstetrics and Gynecology, King Faisal University, Al Hasa, SAU.
Endometriosis is a chronic, inflammatory disease characterized by the presence of endometrial-like tissue outside the uterus, affecting women of reproductive age. It is linked with debilitating pain, infertility, and a notable impact on the patient's quality of life. This review aims to highlight the effectiveness of hormonal therapy, surgical procedures, and complementary therapies in managing endometriosis-related pain, providing a comprehensive overview of current treatment options and their implications for clinical practice.
View Article and Find Full Text PDFTumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model.
Int J Nanomedicine
January 2025
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, People's Republic of China.
Background: Ovarian cancer is difficult to detect in its early stages, and it has a high potential for invasion and metastasis, along with a high rate of recurrence. These factors contribute to the poor prognosis and reduced survival times for patients with this disease. The effectiveness of conventional chemoradiotherapy remains limited.
View Article and Find Full Text PDFChange in Postpartum Visit and Contraception Rates Pre-COVID-19 to Post-Lockdown in Six U.S. Federally Qualified Health Centers.
J Womens Health (Larchmt)
December 2024
Department of Obstetrics and Gynecology, Rush University Medical Center, Chicago, Illinois, USA.
Postpartum care, including contraception, benefits maternal health and decreases mortality, which increased in the United States with COVID-19. Pandemic disruptions to postpartum health care access in vulnerable populations are not well understood. We utilize electronic health record (EHR) data for prenatal patients ( = 2,265) at six urban Federally Qualified Health Centers (FQHCs) from one year prepandemic (January 1, 2019) through one year after the first stay-at-home orders ("lockdown") (March 31, 2021).
View Article and Find Full Text PDFMetabolic control of luteinizing hormone-responsive ovarian steroidogenesis.
J Biol Chem
November 2024
Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska, USA; VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska, USA. Electronic address:
Article Synopsis
- Luteinizing hormone (LH) is key for ovulation and progesterone production across species but knowledge gaps remain about the metabolic processes involved.
- Research using metabolomics in luteal cells shows that LH rapidly activates pathways that increase glycolysis and oxygen use, stimulating lipid production.
- Discoveries highlight the importance of fatty acid synthesis and oxidation in progesterone production, suggesting potential approaches to improve ovarian function and create non-hormonal contraceptives.
Steroid hormones, vitamin D and melatonin in rapidly rotating shift female hospital workers.
Toxicol Lett
January 2025
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Article Synopsis
- The study examined the impact of night-shift work on hormone levels in female hospital workers, particularly focusing on steroid hormones, vitamin D, and melatonin.
- Ninety-seven female participants included nurses on a rapid rotating night-shift schedule and day workers, with various hormonal levels measured in serum and saliva.
- Findings indicated that night-shift work led to higher levels of certain stress-related hormones while not affecting overall circadian rhythms of cortisol and melatonin, nor increasing estradiol levels.
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