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Danggui Buxue decoction regulates autophagy to Improve renal fibrosis in diabetes through miR-27a /PI3K/AKT pathway.
J Ethnopharmacol
January 2025
School of Integrative Medicine, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, 210023, China. Electronic address:
Ethnopharmacological Relevance: Danggui Buxue Decoction (DBD) is a classic traditional Chinese herbal formulation, composed of Astragali Radix (AR) and Angelica Sinensis Radix (ASR) in a ratio of 5:1. It is a traditional Chinese medicine classic prescription for nourishing Qi and Yin (vital energy and body fluids), and it is effective in treating various clinical diseases. Diabetic nephropathy (DN) is categorized under "thirsting," "edema," and "turbid urine" in Traditional Chinese Medicine (TCM).
View Article and Find Full Text PDFSchisandra sphenanthera extract modulates sweet taste receptor pathway, IRS/PI3K, AMPK/mTOR pathway and endogenous metabolites against T2DM.
Phytomedicine
January 2025
School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xi'an 712046, PR China; Shaanxi Key Laboratory of Research and Application of"Taibai Qi Yao", Xianyang 712046, PR China. Electronic address:
Article Synopsis
- Schisandra sphenanthera, a fruit used in traditional medicine, is reported to have beneficial effects on diabetes mellitus (DM) by helping with symptoms like prolonged cough and thirst and may aid in diabetes prevention and control.
- The research aims to uncover how Schisandra Sphenanthera (SDP) works against type 2 diabetes mellitus (T2DM) through various scientific methods like biochemical analysis and metabolite assays.
- Findings reveal that SDP can lower blood glucose levels, improve metabolic functions, and activate specific signaling pathways, ultimately leading to therapeutic effects on T2DM and restoring damage in organs like the liver and pancreas.
Central regulation of drinking water in divergently selected high-water-efficient young broiler chickens: A minireview.
J Neuroendocrinol
December 2024
Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USA.
Poultry production is confronting real challenges, including a lofty projected high demand for animal proteins to feed the future, and the need to adapt to planetary boundaries (global warming) with limited natural resources (land, energy, water). Among the most challenging stressors to poultry production sustainability are heat stress (HS) and water uncertainty, that need extensive fundamental and applied research to identify effective strategies. In that regard, our group has recently developed a high-water-efficient broiler (meat-type) chicken line using water conversion ratio (WCR) as a phenotypic trait and defined the hypothalamic molecular mechanisms controlling drinking water under heat stress conditions.
View Article and Find Full Text PDF[Fermentation technology in application of Puerariae Lobatae Radix with medicinal and edible properties: a review].
Zhongguo Zhong Yao Za Zhi
November 2024
Key Laboratory of Modern Chinese Medicine Formulations of Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
Puerariae Lobatae Radix, as a traditional Chinese medicine(TCM) with both medicinal and edible properties, possesses effects such as relieving muscle tension and fever, generating fluids and quenching thirst, and unblocking the meridians and collaterals. Modern fermentation technology, combined with microecology and modern bioengineering, can regulate the fermentation process and efficiently produce fermentation products. In recent years, modern fermentation technology has been widely applied in TCM, enhancing or altering efficacy, reducing toxicity, and expanding the scope of clinical applications.
View Article and Find Full Text PDF[Protective effect of Polygonati Rhizoma aqueous extract on gastric mucosal injury in mice induced by overtaking pungent substances and alcohol via TRAF1/ASK1/JNK pathway].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
This study aims to investigate the effect and potential mechanism of Polygonati Rhizoma aqueous extract in protecting mice from gastric mucosal injury(stomach Yin deficiency). ICR mice were administrated with the mixture of pungent substance extract and alcohol by gavage once a day for 6 weeks to establish the mouse model of gastric mucosal injury with gastric Yin deficiency. The modeled mice were randomized into three groups of model and Polygonati Rhizoma aqueous extract administrated at 0.
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