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miR-32533 Reduces Cognitive Impairment and Amyloid-β Overload by Targeting CREB5-Mediated Signaling Pathways in Alzheimer's Disease.
Adv Sci (Weinh)
January 2025
Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China.
MicroRNAs (miRNAs) are associated with amyloid-β (Aβ) dysmetabolism, a pivotal factor in the pathogenesis of Alzheimer's disease (AD). This study unveiled a novel miRNA, microRNA-32533 (miR-32533), featuring a distinctive base sequence identified through RNA sequencing of the APPswe/PSEN1dE9 (APP/PS1) mouse brain. Its role and underlying mechanisms were subsequently explored.
View Article and Find Full Text PDFTherapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.
Adv Sci (Weinh)
January 2025
Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, P. R. China.
Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells.
View Article and Find Full Text PDF[Prevalence and genetic characteristics of infections among HIV-positive individuals in Jiangxi Province].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
July 2024
Nanchang Municipal Center for Disease Control and Prevention, Base of National Key Laboratory for the Prevention and Control of Infectious Diseases, Nanchang, Jiangxi 330038, China.
Objective: To investigate the prevalence of infection and the distribution of parasite species and genotypes among HIV-positive individuals in Jiangxi Province.
Methods: HIV-positive individuals' sociodemographic and clinical data were collected from three AIDS designated hospitals in Jiangxi Province from January 2022 to March 2023. Subjects' stool samples were collected, and genomic DNA was extracted from stool samples.
[Prevalence of infections in sheep and goats in Anhui Province in 2020].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
July 2024
College of Animal Science, Anhui Science and Technology University; Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, Fengyang, Anhui 233100, China.
Objective: To investigate the prevalence and molecular characteristics of infections in sheep and goats in Anhui Province in 2020, so as to provide insights into ovine anaplasmosis prevention and control.
Methods: A total of 355 fresh blood samples were collected from 7 sheep and goat farms in Linquan County of Fuyang City, Lixin County of Bozhou City, Yu'an District of Lu'an City, Wangjiang County of Anqing City, Nanling County of Wuhu City, and Tianchang City and Fengyang County of Chuzhou City in Anhui Province from June to December 2020. and 16S ribosomal RNA () gene, major surface protein 4 () gene and citric acid synthase () gene were amplified using PCR assay in all blood samples, and the prevalence of , , and infections was calculated in sheep and goats.
HPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
Adv Sci (Weinh)
January 2025
Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing Medical University, Nanjing, 210004, P. R. China.
Although a fraction of functional peptides concealed within long non-coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA-encoded peptides are involved in the malignancy of cervical cancer (CC). Here, a 92-amino acid peptide is discovered, which is named TUBORF, encoded by lncRNA TUBA3FP and highly expressed in CC tissues. TUBORF inhibits ferroptosis to promote the malignant proliferation of CC cells.
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