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A case of a lesion of the central nervous system in Wegener's granulomatosis with neuritis of craniocerebral nerves, granulomas, vasculitis and foci of ishemic necrosis and hemorrhages in the brain tissue is reported. Diagnosis of Wegener's granulomatosis in a female aged 48 years was confirmed morphologically and by detection of specific antibodies. In spite of prednisolone (20 mg/day) and cyclophosphamide treatment (200 mg per week), hemiplegia, aphasia appeared which progressed and resulted in a death of the patient.
View Article and Find Full Text PDFPrimary meningeal sarcomas in two children.
J Neurooncol
April 2001
Institute of Legal Medicine, Ludwig-Maximilians-University, Munich, Germany.
Primary meningeal sarcomas are rare but highly aggressive tumors predominantly affecting children. The clinical course, imaging characteristics and histopathological features of meningeal sarcomas in two pediatric patients are presented. Furthermore, we critically discuss the new WHO classification of these entities comparing them to older descriptions.
View Article and Find Full Text PDF[Autoradiography of NMDA receptors in amygdala-kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepam].
Yao Xue Xue Bao
May 2001
Department of Pediatrics, First Hospital of Beijing Medical University 100034.
Mechanisms underlying tolerance to and dependence on the anticonvulsant effect of clonazepam are not clear. Autoradiography of the NMDA receptors in amygdala-kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepam was carried out. When tolerance developed, the binding of [3H] TCP (N-(1-thieny) cyclohexylpiperidine) to NMDA receptors was found to be increased at the polymorphocellular layer of the right CA1, and decreased at the molecular layer of the cerebellar ansiform lobule.
View Article and Find Full Text PDFThe "concrete" histological diagnosis of cerebral tumours of neuroectodermic origin.
Morphol Embryol (Bucur)
September 1983
The "concrete" histological criteria for establishing the benignity or malignancy of cerebral tumours of neuroectodermic origin (gliomas and medulloblastomas, respectively granulocytomas) may be thus synthetized: 1) the benign tumours have a fibrocellular structure, the neoplastic cells being relatively monomorphous; vascular hyperplasia is absent, as well as necrotic and hemorrhagic foci; 2) the malignant tumours are hyper- and polymorphocellular, the fibrillar component being reduced or absent; vascular hyperplasia as well as the presence of necrotic and/or hemorrhagic foci is a constant characteristic; the tumoral cells often infiltrate the perivascular spaces.
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