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Effect of cumulative dexamethasone dose on the outcome of patients with radiosurgically treated brain metastases in the era of modern oncological therapy.
J Neurosurg
March 2025
1Department of Neurosurgery, Medical University of Vienna.
Objective: Recent treatment guidelines state that in patients with asymptomatic brain metastases (BMs), local treatment can be delayed until there is evidence of intracranial progression. However, while patients with symptomatic BMs typically require dexamethasone treatment, recent data on the impact of this medication on the outcomes of patients with BMs are lacking. Therefore, the authors conducted a prospective study to evaluate concomitant dexamethasone treatment in a population of radiosurgically treated patients with BMs from non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFConstraints on Axions from Patchy Screening of the Cosmic Microwave Background.
Phys Rev Lett
February 2025
Perimeter Institute for Theoretical Physics, 31 Caroline Street North, Waterloo, Ontario N2L 2Y5, Canada.
The resonant conversion of cosmic microwave background (CMB) photons into axions within large-scale structure induces an anisotropic spectral distortion in CMB temperature maps. Applying state-of-the-art foreground cleaning techniques to Planck CMB observations, we construct maps of axion-induced "patchy screening" of the CMB. We cross-correlate these maps with data from the unWISE galaxy survey and find no evidence of axions.
View Article and Find Full Text PDFDigital Cognitive Behavioral Therapy-Based Treatment for Insomnia, Nightmares, and Posttraumatic Stress Disorder Symptoms in Survivors of Wildfires: Pilot Randomized Feasibility Trial.
JMIR Hum Factors
March 2025
School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Melbourne, Australia.
Background: Symptoms of insomnia, nightmares, and trauma are highly prevalent. However, there are significant barriers to accessing evidence-based treatments for these conditions, leading to poor mental health outcomes.
Objective: This pilot trial evaluated the feasibility of a 4-week, digital self-paced intervention combining cognitive behavioral therapy for insomnia and exposure, relaxation, and rescripting therapy for nightmares in survivors of wildfires from Australia, Canada, and the United States.
Background: Seeking online health information can empower individuals to better understand their health concerns, facilitating their ability to manage their health conditions more effectively. It has the potential to change the likelihood and frequency of health service usage. Although existing literature has demonstrated the prevalence of seeking online health information among different populations, the factors affecting online health information perception and discussions on the associations between seeking online health information and health service utilization are limited.
View Article and Find Full Text PDFDigital Wellness Programs in the Workplace: Meta-Review.
J Med Internet Res
March 2025
Information Technology Department, HEC Montréal, Montreal, QC, Canada.
Background: Corporate wellness programs are increasingly using digital technologies to promote employee health. Digital wellness programs (DWPs) refer to initiatives that deliver health interventions through digital tools. Despite a growing body of evidence on DWPs, the literature remains fragmented across multiple health domains.
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