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Stabilizing complex-Langevin field-theoretic simulations for block copolymer melts.
J Chem Phys
December 2024
Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Complex-Langevin field-theoretic simulations (CL-FTSs) provide an approximation-free method of calculating fluctuation corrections to the self-consistent field theory (SCFT) of block copolymer melts. However, the complex fields are prone to the formation of hot spots, which causes the method to fail. This problem has been attributed to an invariance under complex translations, which allows the system to drift away from the real-valued saddle-point of SCFT.
View Article and Find Full Text PDFHippocampus encoding memory engrams as stable heteroclinic network.
Chaos
December 2024
School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an 710129, China.
Article Synopsis
- The brain's transient activity is illustrated through stable heteroclinic channels (SHCs), which represent pathways of memory formation in its dynamic models, with saddle points symbolizing states of brain activity stability.
- The study builds on a model of hippocampal synaptic networks, showing how short-term memories are transformed into long-term memories as trajectories within these channels, affected by neurotransmitter regulation.
- Numerical findings highlight that while noise can disrupt memory clarity, it also aids in the long-term encoding process, providing a dynamic perspective on how memories are structured and retained.
Kinetically blocked self-assembly of colloidal strings with tunable interactions in magnetic fields.
J Chem Phys
November 2024
Bauman Moscow State Technical University, 2nd Baumanskaya Street 5, 105005 Moscow, Russia.
Tunable self-assembly driven by external electric or magnetic fields is of significant interest in modern soft matter physics. While extensively studied in two-dimensional systems, it remains insufficiently explored in three-dimensional systems. In this study, we investigated the formation of vertical strings from an initial monolayer system of particles deposited on a horizontal substrate under the influence of an external magnetic field using experiments, computer simulations, and theoretical frameworks.
View Article and Find Full Text PDFGABA-Induced Seizure-Like Events Caused by Multi-ionic Interactive Dynamics.
eNeuro
October 2024
School of Systems Science, Beijing Normal University, Beijing 100875, China
Experimental evidence showed that an increase in intracellular chloride concentration [Formula: see text] caused by gamma-aminobutyric acid (GABA) input can promote epileptic firing activity, but the actual mechanisms remain elusive. Here in this theoretical work, we show that influx of chloride and concomitant bicarbonate ion [Formula: see text] efflux upon GABA receptor activation can induce epileptic firing activity by transition of GABA from inhibition to excitation. We analyzed the intrinsic property of neuron firing states as a function of [Formula: see text] We found that as [Formula: see text] increases, the system exhibits a saddle-node bifurcation, above which the neuron exhibits a spectrum of intensive firing, periodic bursting interrupted by depolarization block (DB) state, and eventually a stable DB through a Hopf bifurcation.
View Article and Find Full Text PDFThe Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure.
PLoS Comput Biol
August 2024
Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Slow brain rhythms, for example during slow-wave sleep or pathological conditions like seizures and spreading depolarization, can be accompanied by oscillations in extracellular potassium concentration. Such slow brain rhythms typically have a lower frequency than tonic action-potential firing. They are assumed to arise from network-level mechanisms, involving synaptic interactions and delays, or from intrinsically bursting neurons.
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