AI Article Synopsis
- The study aimed to assess the effectiveness of endoscopic treatment for pancreatic duct stones in patients with chronic pancreatitis, analyzing therapeutic methods and success factors.
- 85% of patients achieved technical success, primarily through piezoelectric extracorporeal shockwave lithotripsy, with no serious complications reported.
- Factors positively influencing treatment outcomes included younger age and stone location; however, certain characteristics, like larger stones or longer disease duration, required more intensive intervention but lost statistical significance upon further data analysis.
Article Abstract
Background: The aim of the study was to evaluate interventional endoscopic management of pancreatic duct stones in patients with chronic pancreatitis by describing therapeutic methods and defining factors that predict technical success.
Methods: Records were retrospectively analyzed for 125 patients with symptoms caused by chronic pancreatitis with pancreatic duct stones (single 43, multiple 82) treated by interventional endoscopy, including extracorporeal shockwave lithotripsy.
Results: Technical success was achieved in 85% of patients (11 patients by mechanical lithotripsy, 114 by piezoelectric extracorporeal shockwave lithotripsy). There were no serious complications from lithotripsy. Univariate analysis disclosed a statistically significant association between treatment success and patient age as well as prepapillary location of stones. A greater therapeutic effort was necessary in patients with stones located in the tail of the pancreas, 2 or more stones, a stone 12 mm or more in diameter, or who have had a longer duration (>8 years) of the disease. However, with exception of the last parameter, correction for multiple testing of data removed statistical significance.
Conclusions: Extracorporeal shockwave lithotripsy enhances endoscopic measures for treatment of pancreatic duct stones when mechanical lithotripsy fails. Middle-aged patients in the early stages of chronic pancreatitis with stones in a prepapillary location proved to be the best candidates for successful treatment. Unfavorable patient-related or morphologic factors can be compensated for through more intense efforts at therapy.
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| http://dx.doi.org/10.1067/mge.2002.128162 | DOI Listing |
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