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A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. | LitMetric
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A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.

Ho-Sang Moon Eric M Jacobson Sonya M Khersonsky Michael R Luzung Daniel P Walsh Wennan Xiong Jae Wook Lee Puja B Parikh Jennifer C Lam Tae-Wook Kang Gustavo R Rosania Alexander F Schier Young-Tae Chang

J Am Chem Soc

Department of Chemistry, New York University, New York, NY 10003, USA.

Published: October 2002

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

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http://dx.doi.org/10.1021/ja026720iDOI Listing

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