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This case report describes an adult man in his 50s with a history of type 2 diabetes and previously well-controlled hypertension, who presented with uncontrolled hypertension, muscle weakness and fatigue. Biochemical testing revealed hypokalaemia. There was no evidence of renal/renovascular disease.

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Licorice toxicity can present with a triad of severe hypokalemia, metabolic alkalosis, and hypertension, particularly in elderly patients. We present the intriguing case of a 78-year-old male who was referred for evaluation of refractory hypokalemia and newly developed hypertension. Despite an unremarkable systemic review and minimal symptoms, a detailed dietary history revealed significant daily consumption of licorice, initially believed by the patient to support smoking cessation.

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Article Synopsis
  • Primary aldosteronism is marked by high aldosterone and low renin levels, making diagnosis complex when severe hydronephrosis coexists, which can falsely affect test results.
  • A 54-year-old man with a history of hypertension and severe hypokalemia faced misdiagnosis of primary aldosteronism due to consistently negative aldosterone-to-renin ratio tests stemming from coinciding severe hydronephrosis.
  • After conducting additional tests, including a saline stress test and adrenal vein sampling, the patient underwent successful laparoscopic removal of an adrenal adenoma, leading to initial renal issues but eventual recovery of renal function and potassium levels.
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Background: Malignant hypertension has not disappeared and remains the most severe form of hypertension. More than 100 years after its description, many points remain unanswered. Mechanisms, definitions, and optimal treatment are still controversial.

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Segmental Adrenal Venous Sampling in Unilateral Primary Aldosteronism With Apparent Bilateral Aldosterone Suppression.

JCEM Case Rep

September 2024

Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Yufu City, Oita 879-5593, Japan.

Apparent bilateral adrenal suppression (ABAS), where aldosterone/cortisol ratios in both adrenal veins are lower than in the inferior vena cava, yields uninterpretable adrenal venous sampling (AVS) results and is poorly understood. A 57-year-old male with hypertension and spontaneous hypokalemia was admitted to our hospital. Confirmatory tests established a diagnosis of primary aldosteronism (PA).

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