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Clinical and pathological characteristics of OPDM4 patients in advanced disease.

Muscle Nerve

October 2024

Department of Neurology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Introduction/aims: Oculopharyngodistal myopathy type 4 (OPDM4) arises from a CGG repeat expansion in the 5' UTR of the RILPL1 gene. Reported cases of OPDM4 have been limited. The aim of this study was to investigate the clinical and myopathological characteristics of OPDM4 patients with advanced disease.

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Monosodium glutamate (MSG) is a flavor enhancer commonly used in modern nutrition. In this study, it was aimed to determine the effect of in ovo administered MSG on the embryonic development of thymus, bursa of Fabricius, and percentages of alpha-naphthyl acetate esterase (ANAE) positive lymphocyte by using histological, histometrical, and enzyme histochemical methods in chickens. For this purpose, 410 fertile eggs were used.

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Bisphenol A (BPA), one of the endocrine disrupting chemicals, is the object of great concern because of its widespread use throughout the world. In this study, it was aimed to determine the effects of in ovo administrated BPA on the bursa of Fabricius and percentage of acid phosphatase positive lymphocyte in peripheral blood by means of histological and enzyme histochemical methods. For this purpose, 310 fertile eggs of Isa Brown laying parent stock were used.

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Background/aims: The aim of the present study was to determine the changes on the small intestine in mice during pregnancy using histological, enzyme histochemical, and immunohistochemical methods.

Materials And Methods: A total of 24 Swiss albino female mice were divided as non-pregnant/control, first week, second week, and third week of pregnancy (n=6). Tissue samples obtained from the duodenum, jejunum, and ileum were processed by means of routine histological techniques and stained with Crossmon's triple staining.

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Innervation of the human spleen: A complete hilum-embedding approach.

Brain Behav Immun

March 2019

Department of Anatomy & Embryology, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands.

Introduction: The spleen is hypothesized to play a role in the autonomic nervous system (ANS)-mediated control of host defence, but the neuroanatomical evidence for this assumption rests on a sparse number of studies, which mutually disagree with respect to the existence of cholinergic or vagal innervation.

Methods: We conducted an immuno- and enzyme-histochemical study of the innervation of the human spleen using a complete hilum-embedding approach to ensure that only nerves that entered or left the spleen were studied, and that all splenic nerves were included in the sampled area. Furthermore, a complete embedded spleen was serially sectioned to prepare a 3D reconstruction of the hilar nerve plexus.

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