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Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages.
Sci Adv
January 2025
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mitochondrial electron transport chain (ETC) function modulates macrophage biology; however, mechanisms underlying mitochondria ETC control of macrophage immune responses are not fully understood. Here, we report that mutant mice with mitochondria ETC complex III (CIII)-deficient macrophages exhibit increased susceptibility to influenza A virus (IAV) and LPS-induced endotoxic shock. Cultured bone marrow-derived macrophages (BMDMs) isolated from these mitochondria CIII-deficient mice released less IL-10 than controls following TLR3 or TLR4 stimulation.
View Article and Find Full Text PDFFamily support and prayer are invaluable coping strategies for our recovery: Experiences of persons living with cardiovascular diseases.
PLoS One
January 2025
Department of Public Health Nursing, School of Nursing and Midwifery, University of Cape Coast, Cape Coast, Ghana.
Background: It is estimated that 61% of deaths caused by Cardiovascular Diseases (CVDs) globally are attributed to lifestyle-related risk factors including tobacco use, alcohol abuse, poor diet, and inadequate physical activity. Meanwhile, inadequate knowledge and misperceptions about CVDs are disproportionately increasing the prevalence of CVDs in Africa. Moreover, pre-diagnosis awareness/knowledge about CVDs among patients is essential in shaping the extent and scope of education to be provided by healthcare workers.
View Article and Find Full Text PDFExploring the association between sleep quality, internet addiction, and related factors among adolescents in Dakshinkali Municipality, Nepal.
PLoS One
January 2025
Department of Public Health, CiST College, Pokhara University, Kathmandu, Nepal.
Background: Poor sleep quality and internet addiction are significant issues affecting adolescents globally, and Nepal is no exception. Several studies have independently assessed the prevalence and associated factors of poor sleep quality and internet addiction among Nepali adolescents and youth, but the relationship between sleep-related attributes and internet addiction remains unexplored. This study aimed to explore the prevalence and contributing factors of poor sleep quality and internet addiction along with the relationship between sleep quality-related attributes and internet addiction.
View Article and Find Full Text PDFPrevalence and risk factors of the most common multimorbidity among Canadian adults.
PLoS One
January 2025
Faculty of Medicine, Division of Population Health and Applied Health Sciences, Clinical Epidemiology Unit, Memorial University, St. John's, Newfoundland and Labrador, Canada.
Background: The number of persons living with multimorbidity-defined as the co-occurrence of at least two chronic conditions in the same individual-is growing globally, especially in developed countries. Traditionally, this increase has been attributed to a growing aging population, sedentary lifestyle, obesity, low socioeconomic status, and individual genetic susceptibility.
Objective: To investigate the prevalence and associated risk factors of the most common multimorbidity (MCM) among Canadian middle-aged and older adults.
Cohort profile: A prospective cohort study on newlywed couples in rural and poor urban Bangladesh.
PLoS One
January 2025
Maternal and Child Health Division, icddr,b, Dhaka, Bangladesh.
Sexual and Reproductive Health and Rights (SRHR) aim to enhance quality of life through safe sexual experiences, reproductive autonomy, and protection against gender-based violence. However, existing SRHR research and interventions in low- and middle-income countries like Bangladesh predominantly focus on women, often understating men and neglecting the nuanced contextual issues faced by married couples. This study contributes to filling this gap by examining SRHR dynamics among newlyweds in rural and poor urban areas of Bangladesh, especially focusing on marital satisfaction, fertility preferences, and post-marriage adaptation mechanisms.
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