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Symmetric Ascending Paralysis Secondary to West Nile Virus.
Case Rep Neurol
July 2023
Academic Infectious Disease Specialist with NCH Graduate Medical Education, Naples, FL, USA.
West Nile virus (WNV) is classified as a , belonging to a Japanese encephalitis subgroup often transmitted via mosquitoes. The classic presentation of a WNV infection usually displays high fevers, myalgias, and headache which can progress to neck stiffness, stupor, and coma (Case Rep Infect Dis. 2020;2020:6501658).
View Article and Find Full Text PDFNeuroimaging of poliomyelitis-like syndrome by Epstein-Barr virus.
An Pediatr (Engl Ed)
September 2023
Unidad de Neuropediatría, Servicio de Pediatría, Centro Hospitalar Universitário de São João, Oporto, Portugal.
Fetuses and infants with Amyoplasia congenita in congenital Zika syndrome: The evidence of a viral cause. A narrative review of 144 cases.
Eur J Paediatr Neurol
January 2023
Department of Neurology, Medical Spectrum Twente, Hospital Enschede, the Netherlands.
Objectives: Amyoplasia congenita is the most frequent type of arthrogryposis causing fetal hypokinesia, leading to congenital contractures at birth. The pathogenesis is thought to be impaired blood circulation to the fetus early in pregnancy, with hypotension and hypoxia damaging the anterior horn cells. In animal studies however a prenatal infection with a poliomyelitis-like viral agent was demonstrated.
View Article and Find Full Text PDFNeutralizing Antibody Given after Paralysis Onset Reduces the Severity of Paralysis Compared to Nonspecific Antibody-Treated Controls in a Mouse Model of EV-D68-Associated Acute Flaccid Myelitis.
Antimicrob Agents Chemother
August 2022
Department of Neurology, University of Colorado, Aurora, Colorado, USA.
Enterovirus D68 (EV-D68) can cause mild to severe respiratory illness and is associated with a poliomyelitis-like paralytic syndrome called acute flaccid myelitis (AFM). Most cases of EV-D68-associated AFM occur in young children who are brought to the clinic after the onset of neurologic symptoms. There are currently no known antiviral therapies for AFM, and it is unknown whether antiviral treatments will be effective if initiated after the onset of neurologic symptoms (when patients are likely to present for medical care).
View Article and Find Full Text PDFRegulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68.
Antiviral Res
April 2021
Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:
The proteostasis network guarantees successful protein synthesis, folding, transportation, and degradation. Mounting evidence has revealed that this network maintains proteome integrity and is linked to cellular physiology, pathology, and virus infection. Human enterovirus A71 (EV-A71) and EV-D68 are suspected causative agents of acute flaccid myelitis, a severe poliomyelitis-like neurologic syndrome with no known cure.
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