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Peripheral blood PD-1 T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications.
Int Immunopharmacol
January 2025
Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China. Electronic address:
A shift toward a T cell exhaustion phenotype is associated with the upregulation of expression of programmed cell death protein 1 (PD-1) on T lymphocytes in patients with malignant solid tumors. The interaction between PD-1 and programmed death-ligand 1 (PD-L1) inhibits PD-1 T lymphocyte function, impacting their anti-tumor immune activity. Immune checkpoint inhibitors targeting PD-1/PD-L1 have revolutionized the treatment of various solid malignancies, improving therapeutic efficacy and survival outcomes.
View Article and Find Full Text PDFPRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.
J Exp Clin Cancer Res
January 2025
Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Background: Adenoid cystic carcinoma (ACC) is a rare glandular malignancy, commonly originating in salivary glands of the head and neck. Given its protracted growth, ACC is usually diagnosed in advanced stage. Treatment of ACC is limited to surgery and/or adjuvant radiotherapy, which often fails to prevent disease recurrence, and no FDA-approved targeted therapies are currently available.
View Article and Find Full Text PDFPlasma-Activated Medium Inhibited the Proliferation and Migration of Non-Small Cell Lung Cancer A549 Cells in 3D Culture.
Int J Mol Sci
December 2024
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Lung cancer is the most common type of malignant tumor worldwide. Plasma-activated medium (PAM) is an innovative cancer treatment method that has received considerable scientific attention. The objective of this study is to evaluate the effects of PAM on the anti-tumor characteristics of non-small cell lung cancer (NSCLC) cells in two-dimensional (2D) and three-dimensional (3D) cultures.
View Article and Find Full Text PDFMetabolic Crossroad Between Macrophages and Cancer Cells: Overview of Hepatocellular Carcinoma.
Biomedicines
November 2024
Department of Basic and Applied Science, University of Basilicata, 85100 Potenza, Italy.
The metabolic interplay between macrophages and cancer cells mirrors the plasticity of both kinds of cells, which adapt to the microenvironment by sustaining cell growth and proliferation. In this way, cancer cells induce macrophage polarization, and, on the other hand, tumor-associated macrophages (TAMs) contribute to the survival of cancer cells. In a simplified manner, macrophages can assume two opposite subtypes: M1, pro-inflammatory and anti-tumor phenotype, and M2, anti-inflammatory and protumor phenotype.
View Article and Find Full Text PDFA comprehensive overview of tolerogenic vaccine adjuvants and their modes of action.
Front Immunol
January 2025
Amgen Research, Amgen Inc., South San Francisco, CA, United States.
Article Synopsis
- Tolerogenic vaccines aim to create immune tolerance specifically for disease-related antigens, offering a safer alternative to broad immunosuppression, which can lead to infections and weakened anti-tumor responses.
- They work by promoting certain immune cells that help regulate and suppress harmful immune responses, thus targeting conditions like autoimmunity and transplant rejection.
- The design of these vaccines varies, often involving a relevant antigen paired with a tolerogenic adjuvant that enhances their effectiveness by creating a more favorable immune response through multiple mechanisms.
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