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Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring. | LitMetric
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Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring.

Harriet W Hamilton Gisele Nishiguchi Susan E Hagen John D Domagala Peter C Weber Stephen Gracheck Stefanie L Boulware Eric C Nordby Hidetsura Cho Takeshi Nakamura Satoru Ikeda Wataru Watanabe

Bioorg Med Chem Lett

Department of Chemistry, Pfizer Global R&D, Ann Arbor, MI 48118, USA.

Published: October 2002

A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.

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http://dx.doi.org/10.1016/s0960-894x(02)00578-4DOI Listing

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